Tetrodotoxin sensitivity of high K+-induced 86Rb efflux in the duodenal circular muscle of pigs.
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概要
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The <SUP>86</SUP>Rb efflux by high K<SUP>+</SUP> was measured simultaneously during the mechanical responses in pig duodenal circular muscle using a superfusion technique. A slightly higher K<SUP>+</SUP> (17.7-23.6 mM) simultaneously induced tetrodotoxin (TTX)-sensitive relaxation and <SUP>86</SUP>Rb efflux. Much higher K<SUP>+</SUP> (47.2-143.4 mM) contracted and also increased the <SUP>86</SUP>Rb efflux markedly, but the extent of TTX-sensitive efflux remained the same as the one at 17.7-23.6 mM K<SUP>+</SUP>, indicating that the TTX-insensitive efflux was contraction-related. The former efflux may lead to hyperpolarization linked to relaxation.
- 公益社団法人 日本薬理学会の論文
著者
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Kondoh Takashi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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KONDOH Takashi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Kondoh Takashi
Department of Applied Chemistry, Faculty of Engineering, Keio University
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