Suppression of spontaneous calcium spikes and contraction in isolated portal veins of mice by gingerols and chemically related compounds.
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概要
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The suppression of spontaneous Ca<SUP>2+</SUP> spikes and isometric contractions by gingerols and their chemically related compounds was examined using the single sucrose gap method. Most of the congeners tested suppressed spontaneous contraction, which was not necessarily accompanied by the suppression of Ca<SUP>2+</SUP> spikes. The most potent analogues for Ca<SUP>2+</SUP> spike suppression were (±)-[6]-gingerol (0.3 mM) and (±)-yakuchinone-A (0.3 mM). These compounds also strongly inhibited spontaneous contraction. In contrast, (±)-[8]-gingerol (0.3 mM) inhibited the contraction without changing the Ca<SUP>2+</SUP> spikes. These results suggest that the inhibition of spontaneous contraction induced by (±)-[6]-gingerol, but not by (±)-[8]-gingerol, is due to the Ca<SUP>2+</SUP> spike suppression.
- 公益社団法人 日本薬理学会の論文
著者
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Shioiri Takayuki
Department of Applied Biological Chemistry, Faculty of Agriculture, Meijo University
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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SHIOIRI Takayuki
Department of Synthetic Organic Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
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PANCHO Leonora-Rivera
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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