An Effective Synthesis of 5,4′-Disubstituted Flavones via a Cesium Enolate Assisted Intramolecular ipso-Substitution Reaction
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概要
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A variety of 5,4′-disubstituted flavones, which are anticipated to be androgen receptor antagonists to treat diseases mediated by the androgen receptor, were synthesized. It was found that an intramolecular ipso-substitution reaction via cesium enolate using 2-fluoro-6-hydroxyacetophenone and various benzoyl chlorides was effective in the preparation of 5-hydroxy-4′-alkylflavones.
- 公益社団法人 日本薬学会の論文
著者
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Takeda Masaki
Department Of Electrical Engineering Faculty Of Science And Technology Tokyo University Of Science
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MATSUGI Masato
Department of Materials Chemistry, Graduate School of Engineering, Osaka University
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Tamura Hiroto
Department Of Applied Biological Chemistry Meijo University
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Takahashi Ayano
Department of Applied Biological Chemistry, Faculty of Agriculture, Meijo University
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Tazaki Takahide
Department of Applied Biological Chemistry, Faculty of Agriculture, Meijo University
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Shioiri Takayuki
Department of Applied Biological Chemistry, Faculty of Agriculture, Meijo University
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Matsugi Masato
Department of Applied Biological Chemistry, Faculty of Agriculture, Meijo University
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Takeda Masaki
Department of Applied Biological Chemistry, Faculty of Agriculture, Meijo University
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Tamura Hiroto
Department of Applied Biological Chemistry, Faculty of Agriculture, Meijo University
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