Inotropic effects of (.+-.)-higenamine and its chemically related components, (+)-R-coclaurine and (+)-S-reticuline, contained in the traditional Sino-Japanese medicines "Bushi" and "Shin-i" in isolated guinea pig papillary muscle.
スポンサーリンク
概要
- 論文の詳細を見る
(±)-Higenamine (Hig, demethylcoclaurine) is a cardiotonic principle from aconite root. (+)-R-Coclaurine (Coc) and (+)-S-reticuline (Ret) are compounds contained in the dried buds of <I>Magnolia salicifolia</I> MAXIM. All of these alkaloids possess a common chemical structure: tetrahydroisoquinoline. Coc and Ret showed negative inotropic effects in contrast to the positive inotropic effects of Hig in papillary muscles of guinea pigs. Coc and Ret shifted to the right the concentration-contraction curves of Hig. Hig shifted in parallel to the left the Ca<SUP>2+</SUP> curve, and it tended to shift to the left the isoproterenol (Isp)-induced response curve. In contrast, Coc and Ret inhibited the Ca<SUP>2+</SUP> curve and the low concentration range of the Isp-induced curve, and it potentiated the high concentration ranges of Ca<SUP>2+</SUP> and Isp. Coc and Ret showed actions that were reversed in direction to those of Hig, as clearly demonstrated in the Ca<SUP>2+</SUP> curve.
- 公益社団法人 日本薬理学会の論文
著者
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Kikuchi Tohru
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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CHUI Li-hua
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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FUJITANI Kazuyoshi
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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KIKUCHI Tohru
Research Institute for Wakan-Yaku (Oriental Medicine), Toyama Medical and Pharmaceutical University
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