Inhibitory Effect of Azelastine on Allergic Itch-Associated Response in Mice Sensitized With Mosquito Salivary Glands Extract
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概要
- 論文の詳細を見る
We examined whether azelastine would inhibit itch-associated responses of mice to mosquito allergy. Repeated injections of mosquito salivary gland extract increased scratching and sensory nerve activity. Azelastine inhibited the increased scratching and nerve activity, while terfenadine was without effects. Dexamethasone did not affect the increased scratching. Azelastine suppressed high K+-induced increase in intracellular free Ca2+ in primary cultures of mouse sensory neurons. Direct inhibition by azelastine of sensory neurons may be at least involved in the anti-pruritic effect of azelastine. Histamine, substance P, and leukotriene B4 may not play a key role in the itching of mosquito allergy.
- 社団法人 日本薬理学会の論文
- 2003-03-01
著者
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ANDOH Tsugunobu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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NOJIMA Hiroshi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Nagai Hiroichi
富山医科薬科大学和漢薬研究所
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medical And Pharmaceutical Science University
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Nojima H
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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OHTSUKA Eiji
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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KAWAI Sanae
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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KAMIMURA Kiyoshi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Nagai Hiroichi
岐阜薬科大学 薬理
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Ohtsuka Eiji
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kawai Sanae
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Nemoto Hideo
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Kamimura Kiyoshi
Toho
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Andoh Tsugunobu
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Nagai Hiroichi
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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Nojima Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Ohu University
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Kamimura Kiyoshi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Kawaharada Soichi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Nojima H
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Nishida Hiroyuki
Department Of Pharmacology Gifu Pharmaceutical University
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Kawai Sanae
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Nojima Hiroshi
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Nemoto Hideo
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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