Pharmacological Differences Between Static and Dynamic Allodynia in Mice With Herpetic or Postherpetic Pain
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概要
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In the present study, we investigated whether dynamic and static allodynia would be developed in the affected dermatome in murine models of herpetic pain and postherpetic neuralgia and pharmacologically characterized the allodynia. Inoculation with herpes simplex virus type-1 on the femur induced skin lesions in the dermatome including the plantar region of the hind paw from day 5 to day 21 after inoculation. Dynamic allodynia became apparent in the hind paw from day 3 to at least day 42. Static allodynia was not obvious during the stage of herpetic pain and gradually increased after the lesion healing. Mexiletine hydrochloride (30 mg/kg, p.o.) and ketamine hydrochloride (50 mg/kg, i.p.) produced a moderate attenuation of static but not dynamic allodynia. Diclofenac sodium (50 mg/kg, i.p.) did not affect both static and dynamic allodynia. Gabapentin (30 mg/kg, p.o.) markedly inhibited both static and dynamic allodynia. Developmental and pharmacological differences between static and dynamic allodynia suggest that independent mechanisms are responsible for dynamic and static allodynia. This murine model may be useful for the study of the mechanisms of dynamic allodynia of herpetic pain or postherpetic neuralgia and the development of new analgesics effective against the dynamic allodynia.
- 社団法人 日本薬理学会の論文
- 2008-11-20
著者
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SASAKI Atsushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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ANDOH Tsugunobu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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TAKAHATA Hiroki
Department of Pharmaceutical Chemistry, Tohoku Pharmaceutical University
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medical And Pharmaceutical Science University
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Kuraishi Yasushi
富山大学 医学薬学研究部応用薬理学
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Sasaki Atsushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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SHIRAKI Kimiyasu
Departments of Virology, Toyama Medical and Pharmaceutical University
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SERIZAWA Kenichi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Andoh Tsugunobu
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Takahata Hiroki
Department Of Pharmaceutical Chemistry Tohoku Pharmaceutical University
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Takahata Hiroki
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Shiraki Kimiyasu
Department Of Virology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Serizawa Kenichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Shiraki K
Department Of Virology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Sasaki Atsushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Sasaki A
Advanced Lcd Technologies Development Center Co. Ltd.
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Takahata Hiroki
Department of Organochemical Design and Synthesis,Faculty of Pharmaceutical Sciences,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
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