Ketene-S,N-acetals as Synthetic Intermediates for Heterocycles. New Synthesis of Multisubstituted Pyridine-2-thiones(Organic,Chemical)

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概要

• 論文の詳細を見る

• Ketene-S,N-acetals reacted with isothiocyanates to give β-aminothiocarbonyl-α-methylthioen-amines, which were transformed into enaminonitriles by carbon-carbon bond formation with malononitriles. Treatment of the enaminonitriles with base aiforded pyridine-2-thiones. In addition, bis-lithio-ketene-S,N-acetals, generated from the enaminonitriles and n-BuLi, reacted with alkyl halides to give 3-alkylpyridine-2-thiones.

• 公益社団法人日本薬学会の論文
• 1987-08-25

著者

• Takahata H

  Tanabe Seiyaku Co. Ltd. Osaka Jpn

• Yamazaki T

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Takahata Hiroki

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Takahata Hiroki

  Faculty Of Pharmaceutical Sciences Tayama Medical & Pharmaceutical University

• WANG ENG

  Faculty of Pharmaceutical Sciences, Tayama Medical & Pharmaceutical University

• NAKAJIMA TOMOKO

  Faculty of Pharmaceutical Sciences, Tayama Medical & Pharmaceutical University

• YAMAZAKI TAKAO

  Faculty of Pharmaceutical Sciences, Tayama Medical & Pharmaceutical University

• Wang Eng

  Faculty Of Pharmaceutical Sciences Tayama Medical & Pharmaceutical University

• Nakajima T

  Faculty Of Pharmaceutical Sciences Tayama Medical & Pharmaceutical University

• Yamazaki Takao

  Faculty Of Engineering Shinshu University

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