Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice
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概要
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We investigated whether the descending noradrenergic system regulates allergic itch. Mosquito allergy of the hind paw elicited biting, an itch-related response, in sensitized mice. The biting was inhibited by intrathecal clonidine and reversed by yohimbine, an α2-adrenoceptor antagonist. The biting was increased by intrathecal pretreatment with the catecholaminergic neurotoxin 6-hydroxydopamine and the α-adrenoceptor antagonist phentolamine but not the serotonergic neurotoxin 5,7-dihydroxytryptamine. We propose that α2-adrenoceptors are involved in the inhibition of allergic itch in the spinal cord and that the descending noradrenergic system exerts a tonic inhibition on the itch signaling. The serotonergic system may not be involved.
著者
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OMORI Yu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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ANDOH Tsugunobu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Omori Yu
富山大学 医学薬学研究部応用薬理学
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Omori Yu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Gotoh Yoshikazu
Department of Cardiology, Kasumigaura Hospital, Tokyo Medical College
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Andoh Tsugunobu
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Gotoh Yoshikazu
Department Of Applied Microbial Technology Kumamoto Institute Of Technology
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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