Inhibitory Effect of Methanol Extract of Ganoderma lucidum on Acute Itch-Associated Responses in Mice
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概要
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In this study, the antipruritic effect of the methanol extract of Ganoderma lucidum (MEGL) was studied in mice. Oral administration of MEGL (10—1000 mg/kg) produced a dose-dependent inhibition of scratching, an itch-related response, induced by intradermal 5-hydroxytryptamine (5-HT) (100 nmol/site), α-methyl-5-HT (100 nmol/site), and proteinase-activated receptor-2 (PAR2)-activating peptide SLIGRL-NH2 (50 nmol/site). However, MEGL (100—1000 mg/kg) did not inhibit the scratching induced by histamine (100 nmol/site), substance P (100 nmol/site), and compound 48/80 (10 μg/site). These results raise the possibility that MEGL is effective against pruritus mediated by proteinases and 5-HT and that primary afferents expressing PAR2 and 5-HT2A receptors are the sites of its action.
著者
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Lee Jung-bum
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Uni
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ANDOH Tsugunobu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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KONNO Mitsuhiro
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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HATTORI Masao
Division of Metabolic Engineering, Institute of Natural Medicine, University of Toyama
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Zhang Qun
Department of Physical Electronics, Tokyo Institute of Technology
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Andoh Tsugunobu
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Hattori Masao
Division Of Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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Zhang Qun
Department Of Mathematics South-central University For Ethnic Communities
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Zhang Qun
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Lee Jung-Bum
Department of Pharmacognosy, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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Kuraishi Yasushi
Department of Applied Pharmacology, University of Toyama
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Konno Mitsuhiro
Department of Applied Pharmacology, University of Toyama
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Zhang Qun
Department of Applied Pharmacology, University of Toyama
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