INFLUENCE OF AGING ON SERUM DEHYDROEPIANDROSTERONE, DHA SULFATE AND 11-DEOXY-17-KETOSTEROIDS IN WOMEN
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概要
- 論文の詳細を見る
副腎性Androgensの分泌に年齢依存性がみられることは尿中17-KSや血中17-KSあるいはDehydronepiandrosterone Sulfate(DHA-S)などがAgingにより低下することから知られているが,血中遊離型DHAについての報告は少なく,またこれら副腎性Androgensの年齢的推移の詳細とそれらの意義については充分解明されていない.今回5-86歳の健康女性の多数例を対象として,血清DHA,DHA-Sおよび11-deoxy-17-KSをRIAにて測定L,それらの暦年齢による変動について比較検討した.いずれも思春期以前には低値を示すが,思春期開始頃より急増し,20歳前後にピークがみられた.その後DHA値は20歳前後半にはピーク時の1/2に低下し,40歳代(更年期)にやや上昇傾向を示すが,50歳代後半までほぼ同レベルを維持し,60歳以降は50歳代の2/3に低下L,その後ほぼ一定のレベルを保つことが認められた.一方,DHA-S及び11deoxy-17KS値は加齢とともに略ぼ直線的に低下する傾向がみられた.このように血中DHAとDHA-S及び1l-deoxy-17KSの変動パタンには差異がみられ,DHA/DHA-S比やDHA/1l-deoxy-17KS比が重要な意義を有することを認め,この点に注目して末梢血中DHAとDHA-S値への副腎と卵巣の奇与の程度の相違の面から,血中DHAの年齢的推移について性腺機能の年代的変動との関連において考察した.
- 社団法人日本産科婦人科学会の論文
- 1979-10-01
著者
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SHINOHARA Harumichi
Department of Anatomy, Kanazawa Medical University
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Akasofu Kazutomo
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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赤祖父 一知
Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University
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Araki Katsumi
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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Araki Katsumi
Department Of Chemistry Nagaoka University Of Technology
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Nishida Etsuro
Department Of Obstetrics And Gynecology School Of Medicine Kanazawa University
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Tomita Yoshimasa
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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Tomita Yoshimasa
Department Of Neurosurgery Juntendo University Izunagaoka Hospital
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SEKI Kumiko
Department of Obstetrics and Gynecology, School of Medicline, Kanazawa University. Kanazawa
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YAMASHIRO Gen
Department of Obstetrics and Gynecology, School of Medicline, Kanazawa University. Kanazawa
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Shinohara Harumichi
Department Of Obstetrics And Gynecology. School Of Medicine. Kanazawa University. Kanazawa
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Shinohara Harumichi
Department Of Anatomy Kanazawa Medical University
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Seki Kurmko
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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Seki Kumiko
Department Of Environmental And Occupational Health Toho University School Of Medicine
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Yamashiro Gen
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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