EFFECTS OF OF SURGICAL STRESS ON CONCENTRATIONS OF SERUM ANDROGENS IN WOMEN
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概要
- 論文の詳細を見る
手術侵襲時における間脳-下垂体-副腎系の反応については,なお必ずしも充分解明されていない.とくに血中副腎性Androgenの動態に関する報告は殆どみられない.今回,Stress状態下における副腎性Androgenの変動げとその意義を考究する目的で,婦人科開腹手術患者を対象として手術前後における血清Cortisol(COL),Dehydroepiandmsterone(DHA),DHA sufate(DHA-S),11-Deoxy-17-KSおよびTestosterone(T)の動態について検討した.COLは麻酔開始とともに上昇,術中さらに上昇し術後3-4時間目にピークを示した.その後は逐目的に漸次低下するが,術後2週間目でも術前値に比しやや高値を示すことが認められた.DHAは手術当日より翌朝 (術後第1日目) にかけてCOLと同様にパラレルに変動することが認められたが,術後第2日目には術前値に復し以降術後第14日目までほぼ同じレベルを維持した.一方DHA-Sおよび11-Deoxy-17-KSは手術日においては有意の上昇を示さず手術日翌朝より上昇し,術後第1-3日目にピークを示し,その後低下するパターンがみられた.なおTでは術後の低下傾向が認められた.以上の結果から,手術襲時にはDHAはCOLとともにその分泌が亢進し,その後DHA⇄DHA-Sと相互転換することにより,侵襲それ自体に対し,また術後の回復過程においてCOLとともに重要な役割を演じていることが示唆された.
- 社団法人日本産科婦人科学会の論文
- 1979-06-01
著者
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SHINOHARA Harumichi
Department of Anatomy, Kanazawa Medical University
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Akasofu Kazutomo
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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Araki Katsumi
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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Araki Katsumi
Department Of Chemistry Nagaoka University Of Technology
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Nishida Etsuro
Department Of Obstetrics And Gynecology School Of Medicine Kanazawa University
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Tomita Yoshimasa
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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Tomita Yoshimasa
Department Of Neurosurgery Juntendo University Izunagaoka Hospital
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YAMASHIRO Gen
Department of Obstetrics and Gynecology, School of Medicline, Kanazawa University. Kanazawa
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SEKI Kurmko
Department of Obstetrics and Gynecology. School of Medicine. Kanazawa University. Kanazawa
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Shinohara Harumichi
Department Of Obstetrics And Gynecology. School Of Medicine. Kanazawa University. Kanazawa
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Shinohara Harumichi
Department Of Anatomy Kanazawa Medical University
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Seki Kurmko
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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Yamashiro Gen
Department Of Obstetrics And Gynecology School Of Medicline Kanazawa University. Kanazawa
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