Sequence Fourier Analysis of a Specific Protein–DNA (RNA) Interaction; an Intermolecular Frequency Symmetry
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概要
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Here, we first report that a specific protein–DNA (RNA) interaction between p53 protein and divergent I kappa B kinase interacting protein (IKIP)-Apaf1 DNA promoter region, and between poliovirus 3CD protein and the 5′ terminal region of the RNA sequence can be successfully elucidated with a sequence Fourier analysis, alike various specific protein–protein interactions described previously. Based on these, the intermolecular frequency symmetry would be evolutionarily conserved in a specific interaction of the bioactive structure of various long-chain sequences. In addition, the symmetry is fairly sensitive to a substitution (or a point mutation) on the sequence.
- 公益社団法人 日本薬学会の論文
著者
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NUMAO Naganori
BioFrontier Institute Inc.
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Numao Naganori
Biofrontier Inst. Inc.
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Kamimoto Yoshihito
Kanagawa Industrial Technology Center
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