A Novel Synthetic Approach to 2,2,2-Trifluoroethylidene Derivatives from Ketones
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概要
- 論文の詳細を見る
An approach to 2,2,2-trifluoroethylidene derivatives from ketones was explored by employing the Corey-Winter's reductive elimination of 4-trifluoromethyl-1,3-dioxolane-2-thiones to 2,2,2-trifluoroethylidene derivatives as a key step. The 1,3-dioxolane-2-thione derivatives were readily prepared from ketones in five steps by sequential formation of O-silylated cyanohydrins, reduction, addition of trifluoromethyltrimethylsilane, desilylation, and formation of the 1,3-dioxolane-2-thione system.
- 公益社団法人日本薬学会の論文
- 1997-01-15
著者
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Nakajima N
Biotechnology Center Toyama Prefectural University
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KATOH Tadashi
Sagami Chemical Research Center
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Kaneko Satoru
Sagami Chemical Research Center
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NAKAJIMA Noriyuki
Sagami Chemical Research Center
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TERASHIMA Shiro
Sagami Chemical Research Center
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Terashima S
Sagami Chemical Res. Center Kanagawa Jpn
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Terashima Shiro
Sagami Chemical Res. Inst.
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Kato Tadashi
Sagami Chemical Research Center
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