Nitrone cycloaddition route to the 1.BETA.-methylcarbapenem key intermediate.
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概要
- 論文の詳細を見る
The 1β-methylcarbapenem key intermediate, (3<I>S</I>,4<I>S</I>)-3-[(<I>R</I>)-1-(<I>t</I>-butyldimethylsilyloxy)ethyl]-4-[(<I>R</I>)-1-carboxyethyl]-2-azetidinone, was prepared from (<I>S</I>)-methyl 3-hydroxy-2-methylpropionate by employing 1,3-dipolar cycloaddition of the chiral nitrone with benzyl crotonate as a key reaction.
- 公益社団法人 日本化学会の論文
著者
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Terashima Shiro
Sagami Chemical Res. Inst.
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KIMURA YOSHIKAZU
Sagami Chemical Research Center
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Ito Yoshio
Sagami Chemical Research Center
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