Total Synthesis of (±)-Gleenol and (±)-Axenol via a Functionalized Spiro[4.5]decane
スポンサーリンク
概要
- 論文の詳細を見る
Total synthesis of the biologically important axane sesquiterpenes, gleenol (1) and axenol (2), was accomplished through a readily available spiro[4.5]decane. The key features of the synthesis of 1 and 2 include Claisen rearrangement to afford the multi-functionalized spiro[4.5]decane 4 as a single diastereomer in excellent yield, installation of the C7 isopropyl group via ketene dithioacetal instead of direct alkylation and a diastereoselective reduction of ketone under the Birch conditions.
- 公益社団法人日本薬学会の論文
- 2007-11-01
著者
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Kobayashi Susumu
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kobayashi Susumu
Department Of Pharmaceutical Sciences Tokyo University Of Science
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Nakazaki Atsuo
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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ERA Tomohiro
Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Era Tomohiro
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Nakazaki Atsuo
Fac. Of Pharmaceutical Sciences Tokyo Univ. Of Sci. (rikadai)
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