Synthesis of Fluorescence-Labeled Galβ1-3Fuc and Galβ1-4Fuc as Probes for the Endogenous Glyco-Epitope Recognized by Galectins in Caenorhabditis elegans
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概要
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To search for the endogenous glyco-epitope in Caenorhabditis elegans, we synthesized labeled Galβ1-3Fuc and Galβ1-4Fuc and examined their binding affinity for C. elegans galectin LEC-6 using frontal affinity chromatography analysis. We developed a new strategy for synthesizing the labeled saccharides, in which the labeling unit, the 2-aminopyridine moiety, is coupled with a spacer unit derived from D-mannitol. Our results indicate that Galβ1-4Fuc is the endogenous glyco-epitope present in C. elegans N-glycans.
著者
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TAKAHASHI Hideyo
School of Medicine,Chiba University
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NATSUGARI Hideaki
School of Pharmaceutical Sciences, Teikyo University
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Kobayashi Susumu
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Natsugari Hideaki
School Of Pharmaceutical Sciences Teikyo Univ.
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Kasai Ken-ichi
School Of Pharmaceutical Sciences Teikyo Univ.
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Nishiyama Kazusa
School of Pharmaceutical Sciences, Teikyo University
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Yamada Atsushi
School of Pharmaceutical Sciences, Teikyo University
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Takahashi Miki
School of Pharmaceutical Sciences, Teikyo University
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Takeuchi Tomoharu
School of Pharmaceutical Sciences, Teikyo University
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Kasai Ken-ichi
School of Pharmaceutical Sciences, Teikyo University
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