Inhibitory Effect of Sulfoquinovosyl Diacylglycerol on Prokaryotic DNA Polymerase I Activity and Cell Growth of Escherichia coli

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概要

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• We isolated the glycolipids fraction from spinach (Spinacia oleracea L.) and found that the fraction inhibited the activities of prokaryotic DNA polymerase I from Escherichia coli (E. coli) and cell growth of E. coli. The fraction contained mainly three glycolipids, monogalactosyl diacylglycerol (MGDG), digalactosyl diacylglycerol (DGDG) and sulfoquinovosyl diacylglycerol (SQDG), and purified SQDG inhibited these activities, however, purified MGDG and DGDG had no influence. In the tested strains of E. coli, SQDG inhibited the cell proliferation of the JM109 strain. It could be considered that a SQDG-containing thylakoid membrane in plant chloroplasts might have anti-bacterial activity.

著者

• YOSHIDA Hiromi

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• MIZUSHINA Yoshiyuki

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• Shimada Hiroaki

  Division Of Plant Biotechnology Tissue Engineering Research Center Tokyo University Of Science

• Kobayashi Susumu

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• Sugawara Fumio

  Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University

• Kuramochi Kouji

  Department Of Applied Biological Chemistry The University Of Tokyo

• FURUKAWA Tomoyuki

  Division of Plant Biotechnology, Tissue Engineering Research Center, Tokyo University of Science

• Takikawa Hirosato

  Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University

• Nishida Masayuki

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• Hada Takahiko

  Hada Giken Co. Ltd.

• Iijima Hiroshi

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• Furukawa Tomoyuki

  Division Of Plant Biotechnology Tissue Engineering Research Center Tokyo University Of Science

• Hada Takahiro

  Hada Giken Co. Ltd.

• Shimada Hiroaki

  Division of Plant Biotechnology, Tissue Engineering Research Center, Tokyo University of Science

• Iijima Hiroshi

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• Nishida Masayuki

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• Kuramochi Kouji

  Department of Applied Biological Science, Tokyo University of Science

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