Growth Inhibition and Chromosomal Instability of Cultured Marsupial (Opossum) Cells after Treatment with DNA Polymerase α Inhibitor

スポンサーリンク

概要

• 論文の詳細を見る

• The DNA replication mechanism has been well established for eutherian mammals (placental mammals such as humans, mice, and cattle), but not, to date, for metatherian mammals (marsupials such as kangaroos, koalas, and opossums). In this study, we found that dehydroaltenusin, a selective inhibitor of mammalian (eutherian) DNA polymerase α, clearly suppressed the growth of metatherian (opossum and rat kangaroo) cultured cells. In cultured opossum (OK) cells, dehydroaltenusin also suppressed the progression of DNA replication. These results suggest that dehydroaltenusin inhibits metatherian as well as eutherian DNA replication. Dehydroaltenusin treatment of OK cells engendered fluctuations in the numbers of chromosomes in the OK cells as well as inhibition of cell growth and DNA replication. This suggests that partial inhibition of DNA replication by dehydroaltenusin causes chromosomal instability in cultured cells.

• 社団法人 日本農芸化学会の論文

著者

• MIZUSHINA Yoshiyuki

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• TAKEMURA Masaharu

  Laboratory of Cancer Cell Biology, Research Institute for Disease Mechanism and Control, Nagoya Univ

• KAZAMA Tomoko

  Laboratory of Biology Education, Graduate School of Mathematics and Science Education, Tokyo Univers

• SAKUMA Kurumi

  Laboratory of Biology Education, Graduate School of Mathematics and Science Education, Tokyo Univers

• OSHIMA Teruyoshi

  Laboratory of Biology Education, Graduate School of Mathematics and Science Education, Tokyo Univers

関連論文

• Novel Terpenoids, Trichoderonic Acids A and B Isolated from Trichoderma virens, Are Selective Inhibitors of Family X DNA Polymerases
• The Antinociceptive and Anti-inflammatory Action of the CHCl3-Soluble Phase and Its Main Active Component, Damnacanthal, Isolated from the Root of Morinda citrifolia
• An Ergosterol Peroxide, a Natural Product That Selectively Enhances the Inhibitory Effect of Linoleic Acid on DNA Polymerase β
• Galactosyldiacylglycerol, a Mammalian DNA Polymerase α-Specific Inhibitor from a Sea Alga, Petalonia bingbamiae
• The Cyanogenic Glucoside, Prunasin (D-Mandelonitrile-β-D-Glucoside), Is a Novel Inhibitor of DNA Polymerase β
• Action of a New Mammalian DNA Polymerase Inhibitor, Sulfoquinovosyldiacylglycerol
• Sulfoquinovosyldiacylglycerol, KM043,a New Potent Inhibitor of Eukaryotic DNA Polymerases and HIV-Reverse Transcriptase Type 1 from a Marine Red Alga, Gigartina tenella
• Replication Protein-A Mediates the Association of Calf Thymus DNA Polymerase α-DNA Primase Complex with Guanine-Rich DNA Sequence
• Inhibitory effect of coenzyme Q_1 on eukaryotic DNA polymerase γ and DNA topoisomerase II activities on the growth of a human cancer cell line
• Vitamin K2-derived Compounds Induce Growth Inhibition in Radioresistant Cancer Cells
• Molecular Action Mode of Hippospongic Acid A, an Inhibitor of Gastrulation of Starfish Embryos
• β-Sitosteryl (6’-O-linoleoyl)-glucoside of Soybean (Glycine max L.) Crude Extract Inhibits Y-Family DNA Polymerases
• Some Characteristics of an Alpha-amylase Inhibitor from Phaseolus vulgaris (Cultivar Great Northern) Seeds
• Selective Inhibition of Mammalian DNA Polymerase α by Vitamin D_2 and D_3
• Nucleolar Protein B23.1 Binds to Retinoblastoma Protein and Synergistically Stimulates DNA Polymerase α Activity^1
• Inhibitory Effect of Sulfoquinovosyl Diacylglycerol on Prokaryotic DNA Polymerase I Activity and Cell Growth of Escherichia coli
• A novel DNA topoisomerase inhibitor : dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos
• DNA polymerase γ inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells
• Inhibitory Effect of Mispyric Acid on Mammalian DNA Polymerases
• Three-Dimensional Structural Model Analysis of the Binding Site of an Inhibitor, Nervonic Acid, of Both DNA Polymerase β and HIV-1 Reverse Transcriptase
• Three-Dimensional Structural Model Analysis of the Binding Site of Lithocholic Acid, an Inhibitor of DNA Polymerase β and DNA Topoisomerase II^1
• Novel Terpenoids, Trichoderonic Acids A and B Isolated from Trichoderma virens, Are Selective Inhibitors of Family X DNA Polymerases
• Morinda citrifolia fruit juice prevents ischemic neuronal damage through suppression of the development of post-ischemic glucose intolerance
• Specific Inhibitors of Mammalian DNA Polymerase Species
• Growth Inhibition and Chromosomal Instability of Cultured Marsupial (Opossum) Cells after Treatment with DNA Polymerase α Inhibitor
• Synthesis and DNA Polymerase α and β Inhibitory Activity of Alkyl p-Coumarates and Related Compounds
• Growth Inhibition and Chromosomal Instability of Cultured Marsupial (Opossum) Cells after Treatment with DNA Polymerase α Inhibitor
• Inhibitory effects of catechin derivatives on mammalian DNA polymerase and topoisomerase activities and mouse one-cell zygote development(BIOCHEMICAL ENGINEERING)

もっと見る 閉じる

スポンサーリンク