Inhibitory Effect of Mispyric Acid on Mammalian DNA Polymerases

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概要

• 論文の詳細を見る

• Mispyric acid is a novel natural triterpene dicarboxylic acid which has inhibitory activity against DNA polymerase β (pol β) isolated from the plant, Mischocarpus pyriformis. In this report, we examine the selectivity of the inhibitory activity against mammalian pols and the mode of inhibition in vitro. Natural mispyric acid (compound 1) inhibited the activities of all the mammalian pols tested (pol α, β, γ, δ and ε) with an IC50 value in the range of 3.6–44.5 μM. The inhibition was strongest for pol γ among these five pols. The enantiomer of mispyric acid (compound 2, ent-mispyric acid) had similar effects to those of the natural compound. However, derivatives of compounds 1 and 2 with hydroxyl groups instead of carboxyl groups (i.e., compounds 3 and 4, respectively) exhibited no inhibitory effect on mammalian pols. The moiety of two carboxylic acids in mispyric acid was important for the inhibition of pols, and the stereoisomers of mispyric acid had no inhibitory effect.

• 社団法人 日本農芸化学会の論文

著者

• YOSHIDA Hiromi

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• MIZUSHINA Yoshiyuki

  Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University

• SASAKI Mitsuru

  Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University

• TAKIKAWA Hirosato

  Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University

• Mizushima Y

  Laboratory Of Food And Nutritional Sciences Department Of Nutritional Science Kobe-gakuin University

• IMAMURA Yusuke

  Department of Biosystems Science, Graduate School of Science and Technology, Kobe University

• MORI Kenji

  Insect Pheromone and Traps Division, Fuji Flavor Co., Ltd.

• Sasaki Mitsuru

  Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University

• Takikawa Hirosato

  Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University

• Mori Kenji

  Insect Pheromone And Traps Division Fuji Flavor Co. Ltd.

• SASAKI Mitsuru

  Department of Biosystems Science, Graduate School of Science and Technology, Kobe University

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