K97-0239A and B, new inhibitors of macrophage foam cell formation, produced by Streptomyces sp. K97-0239
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概要
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Streptomyces sp. K97-0239, a soil isolate, was found to produce inhibitors of lipid droplet formation in mouse peritoneal macrophages. Two compounds, K97-0239A and B, were isolated from the culture broth of the producing strain, and their structures were elucidated by spectroscopic analyses including various NMR experiments. They were cyclic lipopeptides comprising 2, 3-diaminopropionic acid, 4-(aminomethyl)-2, 2-dimethyl-5-oxo-1-imidazolidineacetic acid and phenylalanine/leucine as ring units, and 3-(13-hydroxytetradeca-2, 4-dienoylamino)-acrylic acid as lipophilic side chains. They caused a dose-dependent reduction in the number and size of cytosolic lipid droplets in macrophages at least up to 15μM without any cytotoxic effect on macrophages. [14C] Cholesteryl ester synthesis from [14C] oleic acid by macrophages was inhibited by K97-0239s with IC50 values of 1.5-1.7μM.
- 日本学士院の論文
著者
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Namatame I
Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato Univ
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Tomoda Hiroshi
Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato Univ
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Kobayashi Susumu
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Omura Satoshi
Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato Univ
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Tabata Noriko
Kitasato Institute For Life Sciences & Graduate School Of Infection Control Sciences Kitasato Un
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Namatame Ichiji
Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato Univ
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MATSUDA DAISUKE
Faculty Graduate School of Pharmaceutical Sciences, Science University of Tokyo
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Matsuda Daisuke
Graduate School Of Pharmaceutical Sciences Kitasato University
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NAMATAME Ichiji
Kitasato Institute for Life Sciences, Kitasato University
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MATSUDA Daisuke
Faculty of Pharmaceutical Sciences, Tokyo University of Science
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TOMODA Hiroshi
Kitasato Institute for Life Sciences, Kitasato University
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Omura Satoshi
Kitasato Institute
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