In Vitro and in Vivo Anti-oxidant Activity of Hot Water Extract of Basidiomycetes-X, Newly Identified Edible Fungus(Miscellaneous)
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概要
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Basidiomycetes-X (BDM-X) is a novel edible mushroom recently identified as a new fungi species and registered to the database of the NPO organization for International Patent Organism Depositing (IPOD) in the Industrial Technology Institute of Japan (PCT/JP2004/006418). In the present study, we examined anti-oxidant activity of hot water extract of this novel fungus both in vitro and in vivo together with Agaricus Blazei Murill (ABM), a commercially available medicinal mushroom, and other reference antioxidants. As results, the hot water extract of BDM-X showed more potent anti-oxidative actions compared with that of ABM, when evaluated by 1,1'-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, Ferric Reducing Potential (FRP), and also the inhibition of 2,2'-azobis(2-amidino-propane) dihydrochloride (AAPH)-induced lipid peroxidation of rat liver homogenates. Further, the protective activity of BDM-X extract towards lipopolysaccharide (LPS)-induced hepatic oxidative damage was compared with ABM and α-lipoic acid in the mice pre-administered with these antioxidants. It was revealed that all of these antioxidants inhibited the LPS-induced oxidative tissue damage but the hot water extract of BDM-X showed the strongest protection among them. For example, the dose for 50% inhibition of carbonyl formation in liver was 0.53g dry weight/kg body weight/d for BDM-X and the value corresponded to 16mmol of a-lipoic acid as an antioxidant reference/kg body weight/d.
- 公益社団法人日本薬学会の論文
- 2008-01-01
著者
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NAKAJIMA Yuki
Department of Surgery II, Nippon Medical School
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KONISHI Tetsuya
Department of Radiochemistry-Biophysics and Functional Food Sciences, Niigata University of Pharmacy
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Konishi Tetsuya
Department Of Applied Life Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Konishi Tetsuya
Department Of Functional And Analytical Food Sciences Niigata University Of Pharmacy And Applied Lif
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Nakajima Yuki
Department Of Applied Life Sciences Niigata University Of Pharmacy And Applied Life Sciences
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WATANABE Tetsuo
Niigata Fungi Research Institute
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Nakajima Yuki
Department Of Functional And Analytical Food Sciences Niigata University Of Pharmacy And Applied Lif
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Watanabe Tetsuo
Niigata Fungi Res. Inst.
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Nakajima Yuki
Department of Applied Chemistry, Faculty of Engineering, Saitama University, 255 Shimo-okubo, Sakura, Saitama 338-8570, Japan
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