Characteristic Change of Urinary Elastin Peptides and Desmosine in the Aortic Aneurysm

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概要

• 論文の詳細を見る

• To estimate elastin metabolism in aneurysm, urinary levels of desmosine and elastin peptide in patients (n=23,range 54 to 85 years old) with aneurysm were measured by ELISA and compared between two control groups divided by age (<10 years old and >20 years old). The amounts of urinary desmosine and elastin peptide in the aneurysm group were significantly increased compared with those in the order control group (<20 years old). There was a correlation between urinary desmosine and elastin peptide in the young group. On the other hand, no such correlation was observed in the aneurysm group and the older control group. The distribution of the ratio (desmosine/elastin peptide) in the aneurysm group was different from that of the young control group. We conclude that assay of elastin peptide and desmosine in urine are useful in characterizing elastin degradation in a patient with aneurysm.

• 公益社団法人日本薬学会の論文
• 1999-08-15

著者

• SEYAMA Yoshiyuki

  Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences

• Seyama Yoshiyuki

  Department Of Clinical Chemistry Hoshi College Of Pharmacy

• Usami E

  Hoshi Univ. Tokyo Jpn

• OSAKABE Toru

  Hoechst Marion Roussel, Ltd. Product Realization

• USAMI Eiji

  Department of Pharmacy, Chigasaki Municipal Hospital

• SATO Akira

  Second Department of Surgery, Tohoku University School of Medicine

• SASAKI Shigeru

  Second Department of Surgery, Tohoku University School of Medicine

• WATANABE Tetsuo

  Second Department of Surgery, Tohoku University School of Medicine

• Osakabe Toru

  Hoechst Marion Roussel Ltd. Product Realization

• WATANABE Tetsuo

  Niigata Fungi Research Institute

• Sasaki Shigeru

  Second Department Of Surgery Tohoku University School Of Medicine

• Watanabe Tetsuo

  Niigata Fungi Res. Inst.

• Sato Akira

  Second Department Of Surgery Tohoku University School Of Medicine

• SEYAMA YOSHIYUKI

  Department of Biochemistry, Tokyo College of Pharmacy

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