Improvement of the Antiinflammatory and Antiallergic Activity of Bidens pilosa L. var. radiata SCHERFF Treated with Enzyme (Cellulosine)
スポンサーリンク
概要
- 論文の詳細を見る
Bidens pilosa L. var. radiata SCHERFF (Tachiawayukisendangusa: Musashino Miyako Bidens Pilosa (MMBP)) has been reported to have antiinflammatory and antiallergic properties in the treatment of experimental diseases. We studied the antiinflammatory and anti-allergic effects of enzymatic digested MMBP (eMMBP), MMBP treated with Cellulosine, using an experimental inflammatory and allergic model. Oral administration of eMMBP suspension in carboxy-methyl-cellulose sodium solution inhibited the production of IgE 10 days after immunization with 2,4-dinitrophenylate (DNP)-ascaris in mice. Oral administration of eMMBP suspension inhibited dye exudation in rat skin induced by passive cutaneous anaphylaxis (PCA) and chemical mediators (histamine and substance P). The effects of eMMBP on the inhibition of histamine release from mast cells induced by compound 48/80 or antigen-antibody reaction was stronger than that of the hot-water extract (HWex). Caffeic acid and flavonoids (hyperin and isoquercitrin) in eMMBP are increased more than those in HWex of MMBP, as estimated using HPLC. These results suggest that eMMBP has antiinflammatory and antiallergic activity, and that enzymatic digestion enhances its antiallergic activity by the inhibition of histamine release from the mast cells due mainly to an increase in caffeic acid and flavonoids. The enzymatic digestion of MMBP might be useful in enhancing its antiinflammatory and antiallergic activities.
- 公益社団法人日本薬学会の論文
- 2008-06-01
著者
-
Seyama Yoshiyuki
Department Of Clinical Chemistry Hoshi College Of Pharmacy
-
Horiuchi Masako
Department Of Clinical Chemistry Hoshi University
-
SEYAMA YOSHIYUKI
Department of Biochemistry, Tokyo College of Pharmacy
関連論文
- Characterization of the Molecular Interaction between Tropoelastin and DANCE/Fibulin-5
- Proteolytic Release of Latent Transforming Growth Factor-β (TGF-β) Binding Protein-1 (LTBP-1) Fragment in Wound Healing
- Characteristic expression of connective tissue components and matrix metalloproteinases (MMPs) during the development of pressure ulcerations
- Upregulation of rhoA mRNA in Bronchial Smooth Muscle of Antigen-induced Airway Hyperresponsive Rats
- Characterization of an in vitro Model of Calcification in Retinal Pigmented Epithelial Cells
- Accelerated Calcification Represses the Expression of Elastic Fiber Components and Lysyl Oxidase in cultured Bonvine Aortic Smooth Muscle Cells
- Endothelin-1 Down-Regulates Expression of Tropoelastin and Lysyl Oxidase mRNA in Cultured Chick Aortic Smooth Muscle Cells
- Characteristic Change of Urinary Elastin Peptides and Desmosine in the Aortic Aneurysm
- Effects of Bidens pilosa L. var. radiata SCHERFF treated with enzyme on histamine-induced contraction of guinea pig ileum and on histamine release from mast cells
- The Inhibitory Effect of Cacao Liquor Crude Polyphenols (CLP) on Experimental Arteriosclerosis with Calcification in Rat Soft Tissue
- 7-Ketocholesterol, a Major Oxysterol, Promotes Pi-Induced Vascular Calcification in Cultured Smooth Muscle Cells
- Treatment with Vitamin K2 Combined with Bisphosphonates Synergistically Inhibits Calcification in Cultured Smooth Muscle Cells
- Biochemical Analysis of Elastic Fiber Formation with a Frameshift-Mutated Tropoelastin (fmTE) at the C-Terminus of Tropoelastin
- Tropoelastin Inhibits Vascular Calcification via 67-kDa Elastin Binding Protein in Cultured Bovine Aortic Smooth Muscle Cells
- Role of tropoelastin exon 16 in elastic fiber assembly
- Exon 16 deficient human tropoelastin stimulate the MG63 cell proliferation
- Nitric Oxide Stimulates Elastin Expression in Chick Aortic Smooth Muscle Cells
- Effects of Monensin on Tropoelastin Metabolism in Vascular Smooth Muscle Cells: Monensin Causes Intracellular Degradation of Accumulated Tropoelastin
- Modulation of Elastin Expression by Heparin Is Dependent on the Growth Condition of Vascular Smooth Muscle Cells: Up-Regulation of Elastin Expression by Heparin in the Proliferating Cells Is Mediated by the Inhibition of Protein Kinase C Activity
- Antiinflammatory and Antiallergic Activity of Bidens pilosa L. var. radiata SCHERFF
- Comparison of Elastolytic Activity between Experimental Aneurysm and Experimental Diabetes Mellitus
- Effects of Bidens pilosa L. var. radiata SCHERFF on experimental gastric lesion
- Improvement of the Antiinflammatory and Antiallergic Activity of Bidens pilosa L. var. radiata SCHERFF Treated with Enzyme (Cellulosine)
- Atherosclerosis and Matrix Dystrophy
- Effect of Calcitonin on Experimental Osteolathyrism (III) Selective inhibition of collagem resorption by calcitonin
- Effects of Monensln on Tropoelastin Metabolism in Vascular Smooth Muscle Cells: Monensin Causes Intracellular Degradation of Accumulated Tropoelastin.