Comparison of Elastolytic Activity between Experimental Aneurysm and Experimental Diabetes Mellitus
スポンサーリンク
概要
- 論文の詳細を見る
In order to clarify the degradation of elastin under abnormal conditions, we examined the aortic elastolytic activity in rat experimental diabetes mellitus induced by treatment with streptozotocin and in rat experimental aneurysm induced by treatment with an inhibitor of lysyloxidase (β-aminopropionitrile : BAPN). Measurement of the aortic elastolytic activity used ^<14>C-labeled elastin as the substrate, and the determined value was compared with the aortic lysosomal enzyme (acid phosphatase) activity. In the case of experimental diabetes, the aortic elastolytic activity was not changed, but the aortic acid phosphatase activity was significantly increased compared with the control. In the case of the experimental aneurysm, the aortic elastolytic activity measured after 2 and 3 weeks was increased compared with each control. These was a negative correlation (r=-0.435,n=36) between the elastolytic activity and the cross-linking (desmosine) content in the aorta. The ratio of elastolytic activity to desmosine content was significantly increased compared with the control. Therefore, the degradation of aortic elastin in the experimental aneurysm was caused by elastase, not by lysosomal enzymes. We concluded that an elastase-like enzyme mainly contributed to the degradation of elastin in the experimental aneurysm since the inhibitory pattern of the elastolytic activity in the experimental aneurysm was similar to that of pancreatic elastase.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
-
KOBAYASHI Takeshi
Department of Electrical Engineering, Faculty of Engineering Science, Osaka University
-
SEYAMA Yoshiyuki
Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
-
Kobayashi Taketo
Faculty Of Phamaceutical Sciences Josai University
-
Kobayashi Takeshi
Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University
-
Seyama Yoshiyuki
Department Of Clinical Chemistry Hoshi College Of Pharmacy
-
Osakabe T
Nagoya City Univ. Nagoya Jpn
-
OSAKABE Toru
Laboratory for Bone Research, Drug Research Laboratories, Nippon Hoechst Marion Roussel, Ltd.,
-
Kobayashi Takeshi
Department Of Clinical Chemistry Hoshi College Of Pharmacy
-
SEYAMA YOSHIYUKI
Department of Biochemistry, Tokyo College of Pharmacy
関連論文
- Efficient Regeneration from GUS-Transformed Ajuga Hairy Root
- Efficient Culture Method for Production of Plantlets from Mechanically Cut Horseradish Hairy Roots
- Production of Plantlets for Use as Artificial Seeds from Horseradish Hairy Roots Fragmented in a Blender
- Improved Stability of Metal-Insulator-Diamond Semiconductor Interface by Employing BaF_2 Insulator Film
- Bacterial Bloodstream Infection in Neutropenic Adult Patients after Myeloablative Cord Blood Transplantation : Experience of a Single Institution in Japan
- Targeting Hyperthermia for Renal Cell Carcinoma Using Human MN Antigenspecific Magnetoliposomes
- Peptide Array-Based Interaction Assay of Solid-Bound Peptides and Anchorage-Dependant Cells and Its Effectiveness in Cell-Adhesive Peptide Design (BIOINFORMATICS)
- Hidden Markov Model-Based Prediction of Antigenic Peptides That Interact with MHC Class II Molecules
- New Thermophilic Anaerobes That Decompose Crystalline Cellulose
- A Thermophilic Anaerobe (Clostridium species) Utilizing Various Biomass-Derived Carbohydrates
- Production of Acetone and Butanol Using Immobilized Growing-cells of Clostridium acetobutylicum
- Anaerobic Cellulose Digestion and Characterization of the Cultivaton Process in Tower-Type Fermentor
- Continuous Culture of RPMI 8226 Human Cells
- Kinetic Expression for Human Cell Grwoth in a Suspension Culture System
- Monitoring and Control of Cellulolytic Anaerobe Culture by Using Gas Evolved as an Indicator
- Clinical features of adult acute leukemia with 11q23 abnormalities in Japan : a co-operative multicenter study
- Human Immunodeficiency Virus Type 1 Subtype C Exhibits Higher Transactivation Actvity of Tat than Subtypes B and E
- Expression of a Thermostable Cellulase Gene from a Thermophilic Anaerobe in Saccharomyces cerevisiae
- Production of Ethanol in Repeated-Batch Fermentation with Membrane-Type Bioreactor
- Diversity of Cellulases Produced by a Thermophilic Anaerobe Strain NA10
- Molecular Cloning of Ruminococcus albus Cellulase Gene(Biological Chemistry)
- Heat Immunotherapy Using Magnetic Nanoparticles and Dendritic Cells for T-Lymphoma(MEDICAL BIOTECHNOLOGY, Advances in Biomedical Science and Engineering)
- Screening of Cytokines to Enhance Vaccine Effects of Heat Shock Protein 70-Rich Tumor Cell Lysate(MEDICAL BIOTECHNOLOGY, Advances in Biomedical Science and Engineering)
- Complete Regression of Mouse Mammary Carcinoma with a Size Greater than 15 mm by Frequent Repeated Hyperthermia Using Magnetite Nanoparticles
- Selective hyperthermia using magnetoliposomes to target cervical lymph node metastasis in a rabbit tongue tumor model
- Proliferation and Stratification of Keratinocyte on Cultured Amniotic Epithelial Cells for Tissue Engineering(MEDICAL BIOTECHNOLOGY)
- Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma
- Transglutaminase-Mediated Gelatin Matrices Incorporating Cell Adhesion Factors as a Biomaterial for Tissue Engineering
- Radiation-Inducible TNF-α Gene Expression under Stress-Inducible Promoter gadd 153 for Cancer Therapy
- Bystander-Killing Effect and Cyclic Induction of TNF-α Gene under Heat-Inducible Promoter gadd 153
- Colominic Acid Production from Escherichia coli in a Fed-Batch Culture under the Control of Ammonium Ions Using an FIA System
- Effective Lactic Acid Production by Two-Stage Extractive Fermentation
- Time-Course Data Analysis of Gene Expression Profiles Reveals purR Regulon Concerns in Organic Solvent Tolerance in Escherichia coli(Microbial Physiology and Biotechnology)
- OVERPRODUCTION OF FOREIGN GENE PRODUCT IN RECOMBINANT ESCHERICHIA COLI BY IN SITU ADSORPTION OF TRYPTOPHAN
- Optimization of the Expression of a Foreign Gene from Galactose-Inducible Promoter in a Recombinant Yeast
- Increased Production of Cloned β-Galactosidase in Two-Stage Culture of Bacillus amyloliquefaciens
- Effects of Lactate and Ammonium on the Oxygen Uptake Rate of Human Cells
- Prognostic models in patients with non-small-cell lung cancer using artificial neural networks in comparison with logistic regression
- X-Ray Photoelectron Spectroscopy Characterization of Diamond Thin Film Surfaces for Electronic Device Application
- Electrical Properties of Al/(Ba_XCa_)F_2/i-Diamond Metal-Insulator-Semiconductor Structures
- Development of Dual On-Line Analyzer and Its Application to Fed-Batch Lactic Acid Fermentation
- Adaptive On-Line Optimizing Control for Lactic Acid Fermentation
- Preparation of Tumor-Specific Magnetoliposomes and Their Application for Hyperthermia
- Modeling of Consumers' Preferences for Regular Coffee Samples and Its Application to Product Design
- Determination of the Blending Ratio of Regular Coffee Samples by Information Technology
- Multiple fuzzy neural network system for outcome prediction and classification of 220 lymphoma patients on the basis of molecular profiling
- Selection of Causal Gene Sets for Lymphoma Prognostication from Expression Profiling and Construction of Prognostic Fuzzy Neural Network Models(MEDICAL BIOTECHNOLOGY)
- Fuzzy Neural Network Applied to Gene Expression Profiling for Predicting the Prognosis of Diffuse Large B-cell Lymphoma
- Affinity Partitioning of Protein A Using a Magnetic Aqueous Two-Phase System
- Inference of Common Genetic Network Using Fuzzy Adaptive Resonance Theory Associated Matrix Method(BIOINFORMATICS)
- Artificial Neural Network Predictive Model for Allergic Disease Using Single Nucleotide Polymorphisms Data
- Determination of Operating Conditions in Activated Sludge Process Using Fuzzy Neural Network and Genetic Algorithm
- Construction of COD Simulation Model for Activated Sludge Process by Recursive Fuzzy Neural Network
- Construction of COD Simulation Model for-Acivated Sludge Process by Fuzzy Neural Network
- -84- PROGNOSTIC IMPLICATION OF RIGHT AND LEFT VENTRICULAR DYSFUNCTIONS AND EXERCISE TESTING IN THE POST-MYOCARDIAL INFARCTION PATIENT : Congestive Heart Failure : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE C
- -1053-EFFECTS OF ENDOTHELIUM-DERIVED RELAXING FACTOR ON BLOOD PRESSURE AND CENTRAL AUTONOMIC NEVER CONTROL : AN ASSESSMENT USING L-N^G-MONO-METHYLARGININE : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0566-THE IN VIVO MEASUREMENT OF THE MYOCARDIAL INTERSTITIAL POTASSIUM AND LACTATE CONCENTRATIONS IN THE BEATING CANINE HEART USING AN IMPROVED MICRODIALSIS TECHNIQUE
- DIPYRIDAMOLE POTENTIATES EDRF-MEDIATED INHIBITION OF PLATELET AGGREGATION : THE ROLE OF DIPYRIDAMOLE IN VIVO AS A CYCLIC GMP PHOSPHODIESTERASE INHIBITOR : Myocardial Metabolism, Biochemistry : 53 Annual Scientific Meeting, Japanese Circulation Society
- Magnetic Characterization of Magnetite Particles for MR Contrast Agents
- A Preprocessing Method for Inferring Genetic Interaction from Gene Expression Data Using Boolean Algorithm(BIOINFORMATICS)
- Prognostic Predictor with Multiple Fuzzy Neural Models Using Expression Profiles from DNA Microarray for Metastases of Breast Cancer(BIOINFORMATICS)
- Proposal of Reliability Index in Search for Reliable Solutions of Reverse Calculation Based on Fuzzy Neural Network Modeling
- Evaluation of the Alzheimer-Type Dementia by Magnetic Resonance Imaging Using Fuzzy Neural Networks
- Simple and Rapid Cell Growth Assay Using Tetrazolium Violet Coloring Method for Screening of Organic Solvent Tolerant Bacteria
- Construction of an Electroencephalogram-Based Brain-Computer Interface Using an Artificial Neural Network(Welfare Engineering)
- Analysis of Organic Solvent Tolerance in Escherichia coli Using Gene Expression Profiles from DNA Microarrays
- On-Line Control of Glucose Concentration Using An Automatic Glucose Analyzer
- -P97- USEFULNESS OF RIGHT ATRIAL FUNCTION ANALYSIS IN THE PATIENTS WITH HEART DISEASE : RI : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE POTENTIATED THROMBOLYSIS UNDER SELECTIVE INFUSION OF AUTO PLASMIN RICH PLASMA (APRP) : PTCA, Thrombosis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE POTENTIATED THROMBOLYSIS USING AUTOPLASMIN RICH PLASMA (APRP) UNDER SELECTIVELY BLOOD FLOW OBSTRUCTION TRANSIENTLY PRODUCED BY BALLOON-TIP CATHETER : Ischemic Heart Disease (III) : FREE COMMUNICATIONS (III) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC
- RIGHT AND LEFT VENTRICULAR FUNCTION DURING EXERCISE IN PATIENTS WITH CORONARY ARTERY DISEASE : Radio Isotope : 46th Annual Scientific Meeting, Japanese Circulation Society
- POTENTIATION OF TOXICITY AND POSITIVE INOTROPIC EFFECT OF OUABAIN BY FUROSEMIDE IN GUINEA PIG HEART
- The Non-invasive Evaluation of Regional Myocardial Ischemia Studied by a "Stress-injected" Thallium-201 Myocardial Imaging and a Radionuclide Left Ventriculography : Symposium on Myocardial Ischemia
- Inducible Production of Erythropoietin Using New Runaway-Type Vector by Mammalian Cell Culture in Spinner Flask
- Continuous Production of Human Erythropoietin by Immobilized Recombinant L-929 Cells
- Kinetic Study of Hybridoma Metabolism and Antibody Production in Continuous Culture Using Serum-Free Medium
- Immobilization of Animal Cells Using Photo-Crosslinkable Resin
- Effect of Dissolved Oxygen Concentration on Monoclonal Antibody Production in Hybridoma Cell Cultures
- High Cell Density Cultivation of Anchorage-Dependent Cells Using a Novel Macroporous Cellulosic Support
- Formation of Inclusion Complexes between Cyclodextrins and Aromatic Compounds under pressurized Carbon Dioxide
- Effects of Oxygen Aeration on Production of Monoclonal Antibody in Immobilized Hybridoma-Cell Bioreactor
- Purification of Recombinant α-Amylase with Immuno-Affinity Chromatography Using Monoclonal Antibody
- Effective Utilization of Horseradish and Wasabi by Treatment with Supercritical Carbon Dioxide
- Synthesis of Aspartame Precursors by Enzymatic Reaction in Supercritical Carbon Dioxide(Food & Nutrition)
- Brewing of Sake from Rice and Rice-Koji Defatted by Supercritical Carbon Dioxide Treatment
- Removal of Organic Solvent from Antibiotics with Supercritical Carbon Dioxide
- Effect of Treatment with Supercritical Carbon Dioxide on Enzymatic Activity(Food & Nutrition)
- Sterilization of Microorganisms with Supercritical Carbon Dioxide(Food & Nutrition)
- Secretion of Thermophilic Bacterial Cellobiohydrolase in Saccharomyces cerevisiae
- Observation of Capacitance Hunching at the Flat-Band-Voltage in Boron-Doped Diamond Metal/Insulator/Semiconductor Structure
- Efficient MIS Electric Field Effect on Diamond Thin Film Transistors
- Electric Field Effect in Al/SrTiO_3/YBa_2Cu_3O_y Structure in the Normal State
- Dielectric Properties of SrTiO_3 Epitaxial Film and Their Application to Measurement of Work Function of YBa_2Cu_3O_y Epitaxial Film
- Analysis on Electric Field Effect in Al/SrTiO_3/YBa_2Cu_3O_y Structure
- Metal-Insulator-Superconductor Field-Effect-Transistor Using SrTiO_3/YBa_2Cu_3O_y Heteroepitaxial Films
- Epitaxial SrTiO_3 Thin Films Grown by ArF Excimer Laser Deposition
- Overproduction of Thermostable β-Galactosidase in Escherichia coli, Its Purification and Molecular Structure
- Prediction of Occurrence of Heterocapsa circularisquama Red Tide by Means of Fuzzy Neural Network
- Reduction of Pinhole Leakage Current of SrTiO_3 Films by ArF Excimer Laser Deposition with Shadow Mask ("Eclipse Method")
- Improved Surface Smoothness of YBa_2Cu_3O_y Films and Related Multilayers by ArF Excimer Laser Deposition with Shadow Mask "Eclipse Method"