The Inhibitory Effect of Cacao Liquor Crude Polyphenols (CLP) on Experimental Arteriosclerosis with Calcification in Rat Soft Tissue
スポンサーリンク
概要
- 論文の詳細を見る
Cacao liquor crude polyphenols (CLP) contained potent anti-oxidants, such as catechin, and their oligomers. An investigation was conducted on the effects of CLP on experimental arteriosclerosis with calcification in rats, induced by giving vitamin D_2 (2.5×10^5 I. U. /kg) for the first 4 consecutive days with an atherogenic diet (2% cholesterol, 1.5% cholic acid, 0.1% methylthiouracil). The diet was prepared using a vitamin E deficient diet. CLP inhibited the increase of serum lipid peroxides, the increase of calcium (Ca) in the aorta, the increase of Ca and inorganic phosphorus (P) in the aortic elastin fraction, or in the renal Ca and P of the arteriosclerotic rats. Previously, vitamin E and vitamin K_2 showed anti-calcification and radical scavenging activities under the above experimental conditions without vitamin E deficiency. Moreover, CLP reduced lipid peroxides in plasma and in tissue induced by vitamin E deficiency, without maintaining vitamin E levels. It is suggested that the inhibitory effects of CLP on the accumulation of Ca and P in the aorta or kidney were partially due to an anti-oxidant activity.
- 公益社団法人日本薬学会の論文
- 2001-04-01
著者
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OSAKABE Naomi
Functional Foods R&D Laboratory, Meiji Seika Kaisha Ltd.
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TAKIZAWA Toshio
Functional Foods R&D Laboratory, Meiji Seika Kaisha Ltd.
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Osakabe Naomi
Functional Food Research And Development Laboratory Meiji Seika Kaisha Ltd.
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SEYAMA Yoshiyuki
Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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Takizawa Toshio
Functional Food Research And Development Laboratory Meiji Seika Kaisha Ltd.
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Seyama Yoshiyuki
Dep. Of Clinical Chemistry Hoshi Univ.
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Seyama Yoshiyuki
Department Of Clinical Chemistry Hoshi College Of Pharmacy
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HORIUCHI Masako
Department of Clinical Chemistry, Hoshi University
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Takizawa Toshio
Functional Food Research And Development Laboratory Meiji Seika Kaisha
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Horiuchi Masako
星薬科大学 臨床化学教室
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Horiuchi Masako
Department Of Clinical Chemistry Hoshi University
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SEYAMA YOSHIYUKI
Department of Biochemistry, Tokyo College of Pharmacy
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