Recent Progress in α_1-Adrenoceptor Pharmacology
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概要
- 論文の詳細を見る
The adrenoceptors (ARs) play a key role in the modulation of sympathetic nervous system activity and are a site of action for many clinically important therapeutic agents. The α_1-adrenoceptor subtypes (α_<1A>-, α_<1B>-, and α_<1D>-AR) play a prominent role in regulating vascular tone and hypertrophic growth of smooth muscle and cardiac cells. Their functional characteristics with respect to ligand binding and second messenger utilization have been well described. Here, we review recent progress on subtype-specific subcellular localization, participation in signaling cascades, and the pivotal function of α_1-ARs, as delineated through studies on genetically engineered animals. Together, these findings will provide new insights into the physiological and pathophysiological roles of the α_1-ARs.
- 公益社団法人日本薬学会の論文
- 2002-04-01
著者
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TSUJIMOTO Gozoh
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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Hirasawa A
Department Of Gynecology Keio University Hospital
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Hirasawa Akira
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Hirasawa Akira
The Department Of Hematology Yokohama Rosai Hospital For Labour Welfare Corporation
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TANOUE Akito
Department of Pharmacology, National Research Institute for Child Health and Development
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Hirasawa Akira
京都大学 薬学研究科ゲノム創薬科学
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Yamauchi Junji
国立小児病院小児医療研究センター
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Yamauchi Junji
Department Of Molecular Cell Pharmacology National Children's Medical Research Center
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Hirasawa A
Dep. Of Genomic Drug Discovery Sci. Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Hirasawa Akira
Department Of Gynecology Keio University Hospital
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Dep. Of Genomic Drug Discovery Sci. Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Tsujimoto Gozoh
Department Of Molecular Cell Pharmacology National Research Institute For Child Health And Developme
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Tsujimoto Gozoh
Department Of Molecular And Cellular Pharmacology National Children's Medical Research Center
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Tsujimoto Gozoh
Department Of Molecular Cell Pharmacology National Children 's Medical Research Center
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KOSHIMIZU Taka-aki
Department of Molecular, Cell Pharmacology, National Children's Medical Research Center
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Koshimizu Taka-aki
Division Of Molecular Pharmacology Department Of Pharmacology Jichi Medical University
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Koshimizu Taka-aki
Department Of Molecular Cell Pharmacology National Children's Medical Research Center
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Hirasawa Akira
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
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Tanoue Akito
Department Of Molecular Cell Pharmacology National Research Institute For Child Health And Developme
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Higashiguchi Atsushi
Department Of Pathology Keio University School Of Medicine
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Koshimizu Taka-aki
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University
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