Protective Effect of α-Lipoic Acid Against Arsenic Trioxide–Induced Acute Cardiac Toxicity in Rats
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概要
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The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects. We examined whether α-lipoic acid (LA) protects against the ATO-induced cardiac toxicity. In the chronic study, two of four rats suddenly died by the repeated dosing of ATO, whereas no deaths were observed in combination with LA. In the acute study, continuous ECG recording revealed that intravenous injection of ATO caused transient ST-T change, whereas pretreatment with LA abolished the ATO-induced ECG abnormality in all animals. These results suggest that LA protects against the ATO-induced acute cardiac toxicity and subsequent sudden death in rats.
著者
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Ushijima Kentarou
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
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Ando Hitoshi
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
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Fujimura Akio
Division Of Clinical Pharmacology Department Of Pharmacology Jichi Medical University
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Koshimizu Taka-aki
Division Of Molecular Pharmacology Department Of Pharmacology Jichi Medical University
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Oshima Yasuo
Division Of Clinical Pharmacology Department Of Pharmacology Jichi Medical University
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Sasaki Akira
Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University
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Kumazaki Masafumi
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
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Hosohata Keiko
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Japan
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Sasaki Akira
Division Of Clinical Pharmacology Department Of Pharmacology Jichi Medical University
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Ushijima Kentarou
Division Of Clinical Pharmacology Department Of Pharmacology Jichi Medical University
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Ando Hitoshi
Division Of Clinical Pharmacology Department Of Pharmacology Jichi Medical University
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Hosohata Keiko
Division Of Clinical Pharmacology Department Of Pharmacology Jichi Medical University
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Kumazaki Masafumi
Division Of Clinical Pharmacology Department Of Pharmacology Jichi Medical University
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