The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis

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概要

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• Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clock remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NASH) using a custom-made, high-precision DNA chip. C57BL/6J mice fed an atherogenic diet for 5 weeks developed hypercholesterolemia, oxidative stress, and NASH. DNA chip analyses revealed that the atherogenic diet had a great influence on the mRNA expression of a wide range of genes linked to mitochondrial energy production, redox regulation, and carbohydrate and lipid metabolism. However, the rhythmic mRNA expression of the clock genes in the liver remained intact. Most of the circadianly expressed genes also showed 24-h rhythmicity. These findings suggest that the biological clock is protected against such a metabolic derangement as NASH. © 2009 Elsevier Inc. All rights reserved.

• 2009-03-13

著者

• Kaneko Shuichi

  日本医科大学老人病研究所

• Takamura Toshinari

  金沢大学 大学院医学系研究科恒常性制御学

• Fujimura Akio

  Division Of Clinical Pharmacology Department Of Pharmacology Jichi Medical University

• Kaneko Shuichi

  Department Of Disease Control And Homeostacis Kanazawa University Graduate School Of Medical Science

• Kaneko S

  Department Of Internal Medicine (i) School Of Medicine Kanazawa University

• Kaneko Shuichi

  金沢大学 第1内科

• Takamura Toshinari

  First Department Of Internal Medicine School Of Medicine Kanazawa University

• Kaneko Shuichi

  Internal Medicine (i) Kanazawa University School Of Medicine

• Ando Hitoshi

  Department Of Disease Control And Homeostacis Kanazawa University Graduate School Of Medical Science

• Kumazaki Masafumi

  Division Of Clinical Pharmacology Department Of Pharmacology Jichi Medical University

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