Effects of a New Antiarrhythmic Drug, SD-3212, on Canine Ventricular Arrhythmia Models.
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概要
- 論文の詳細を見る
The antiarrhythmic effects of a new antiarrhythmic agent, SD-3212, (-)-(S)-3, 4-Dihydro-2-[5-methoxy-2-[3-[N-methyl-N-[2-[(3, 4-methylene dioxy)phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3-oxo-2H-1, 4-benzothiazine hydrogen fumarate, were investigated using canine models of ventricular arrhythmias, i.e. spontaneously occurring digitalis-, two-stage coronary ligation- and adrenaline-induced arrhythmias. SD-3212 suppressed adrenaline-induced arrhythmia and showed some antiarrhythmic effect on digitalis- and 48hr coronary ligation-arrhythmias. These results indicate that SD-3212 has antiarrhythmic effects common among class IV antiarrhythmic drugs and also has additional efficacy common among class I antiarrhythmic drugs, thus when considering the level of experimental arrhythmias it somewhat resembles propafenone. It may therefore become a clinically useful antiarrhythmic drug among typical class I or class IV antiarrhythmic drugs.
- International Heart Journal刊行会の論文
著者
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Hirasawa Akira
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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HARUNO Akihiko
Department of Pharmacology, Yamanashi Medical College
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MATSUZAKI Takushi
Department of Pharmacology, Yamanashi Medical College
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