Free Fatty Acid Receptors and Drug Discovery(Physiology and Pharmacology of the Gut Nutrient Perception)
スポンサーリンク
概要
- 論文の詳細を見る
Utilizing the human genome database, the recently developed G-protein-coupled receptor (GPCR) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs) and is proposed to play a critical role in a variety of physiologic homeostasis mechanisms. GPR40 and GPR120 are activated by medium- and long-chain FFAs, whereas GPR41 and GPR43 are activated by short-chain FFAs. GPR40, which is preferentially expressed in pancreatic β-cells, mediates insulin secretion. On the other hand, GPR120, which is abundantly expressed in the intestine, functions as a receptor for unsaturated long-chain FFAs and promotes the secretion of glucagon-like peptide-1 (GLP-1). In this review, we summarize the identification, structure, and pharmacology of the receptors and speculate on the respective physiologic roles that FFA receptor family members may play.
- 2008-10-01
著者
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HIRASAWA Akira
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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HARA Takafumi
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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KATSUMA Susumu
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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ADACHI Tetsuya
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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TSUJIMOTO Gozoh
Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sci
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Shimada Kenei
Osaka Ekisaikai Hospital
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Shimada Kenei
Department Of Internal Medicine And Cardiology Osaka City University School Of Medicine
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Shimada Kenei
ベルランド総合病院 循環器内科
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Hara Takafumi
京都大学 薬学研究科ゲノム創薬科学分野
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Hara Takafumi
Dep. Of Genomic Drug Discovery Sci. Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Kim-mitsuyama Shokei
熊本大学 医学教育部生体機能薬理学
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Kim-mitsuyama Shokei
大阪市立大学 医学研究科薬理学
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Shimada Kenei
Department Of Medicine Cardiovascular Division Osaka Ekisaikai Hospital
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Shimada Kenei
Department Of Cardivascular Medicine Osaka Ekisaikai Hospital
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Hirasawa Akira
The Department Of Hematology Yokohama Rosai Hospital For Labour Welfare Corporation
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Shimeno Kenji
Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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Hirasawa Akira
京都大学 薬学研究科ゲノム創薬科学
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Sakata Konomi
Actmce1
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Hanatai Akihisa
First Department Of Internal Medicine Osaka City Unitersity Medical School
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Kim Shokei
大阪市立大学 医学部循環器病態内科学
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Hirasawa A
Dep. Of Genomic Drug Discovery Sci. Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Hirasawa Akira
Department Of Gynecology Keio University Hospital
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Katsuma Susumu
Department Of Genomic Drug Discovery Science Kyoto University Graduate School Of Pharmaceutical Scie
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Katsuma Susumu
Department Of Agricultural And Environmental Biology Graduate School Of Agricultual And Life Science
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Adachi T
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Adachi Tetsuya
Department Of Clinical And Laboratory Medicine Akita University School Of Medicine
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Shiratori Kenichi
Juntendo University Shizuoka Hospital
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Adachi T
Laboratory Of Metabolism Kyoto University Graduate School Of Human And Environmental Studies
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Kim S
大阪市立大学 薬理
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Dep. Of Genomic Drug Discovery Sci. Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Tsujimoto Gozoh
Department Of Molecular Cell Pharmacology National Research Institute For Child Health And Developme
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Tsujimoto Gozoh
Department Of Molecular And Cellular Pharmacology National Children's Medical Research Center
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Tsujimoto Gozoh
Department Of Molecular Cell Pharmacology National Children 's Medical Research Center
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Hirasawa Akira
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
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Higashiguchi Atsushi
Department Of Pathology Keio University School Of Medicine
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Hara Takafumi
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Tsujimoto Gozoh
Department Of Genomic Drug Discovery Science Graduate School Of Pharmaceutical Sciences Kyoto Univer
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Shimamura Kunihiro
Department Of Cardiovascular Medicine Wakayama Medical University
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Hanatani Akihisa
Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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