PGC-1α mRNA Level and Oxidative Capacity of the Plantaris Muscle in Rats with Metabolic Syndrome, Hypertension, and Type 2 Diabetes
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概要
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We examined the fiber profiles and the mRNA levels of peroxisome proliferator-activated receptors (PPARα and PPARδ/β) and of the PPARγ coactivator-1α (PGC-1α) in the plantaris muscles of 15-week-old control (WR), metabolic syndrome (CP), hypertensive (SHR), and type 2 diabetic (GK) rats. The deep regions in the muscles of SHR and GK rats exhibited lower percentages of high-oxidative type I and IIA fibers and higher percentages of low-oxidative type IIB fibers compared with WR and CP rats. The surface regions in the muscles of CP, SHR, and GK rats exhibited lower percentages of high-oxidative type IIA fibers and higher percentages of low-oxidative type IIB fibers compared with WR rats. The muscles of SHR and GK rats had lower oxidative enzyme activity compared with WR rats. The muscles of SHR rats had the lowest PPARδ/β mRNA level. In addition, the muscles of SHR and GK rats had lower PGC-1α mRNA level compared with WR and CP rats. We concluded that the plantaris muscles of rats with hypertension and type 2 diabetes have lower oxidative capacity, which is associated with the decreased level of PGC-1α mRNA.
著者
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Ishioka Noriaki
Department Of Molecular Life Science Tokai University School Of Medicine
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Kondo Hiroyo
Department Of Clininal Nutrition Suzuka University Of Medical Science
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Tsuda Kinsuke
Laboratory Of Metabolism Graduate School Of Human And Environmental Studies Kyoto University
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Fujino Hidemi
Department Of Physical Therapy Faculty Of Health Care Science Himeji Dokkyo University
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Takeda Isao
Department Of Gastroenterology Ogaki Municipal Hospital
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Gu Ning
Department Of Life Science And Engineering Harbin Institute Of Technology
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Nagatomo Fumiko
Laboratory Of Cell Biology And Life Science Graduate School Of Human And Environmental Studies Kyoto University
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Ishihara Akihiko
Laboratory Of Cell Biology And Life Science Graduate School Of Human And Environmental Studies Kyoto University
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