Chronic Exercise Training Down-Regulates TNF-α and Atrogin-1/MAFbx in Mouse Gastrocnemius Muscle Atrophy Induced by Hindlimb Unloading
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概要
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The purpose of this study was to investigate the effect of chronic moderate-intensity training in order to prevent muscle atrophy with a focus on TNF-α and atrogin-1/MAFbx as main proteolytic indicators. Hindlimb unloading model of mice received treadmill running exercise for 1 hr per day during hindlimb unloading period of 6 weeks. The gastrocnemius muscle mass, muscle fiber cross-sectional area, and succinate dehydrogenase (SDH) activity in the muscle fiber were higher in the exercised group, while TNF-α and atrogin-1/MAFbx mRNA expressions were significantly lower. Results in the present study showed that chronic exercise could prevent over expression of TNF-α and atrogin-1/MAFbx in the atrophied skeletal muscle, providing further support to the effects of chronic exercise training on muscle atrophy.
著者
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Murakami Shinichiro
Department Of Anatomy Faculty Of Medicine Okayama University Medical School
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Kondo Hiroyo
Department Of Clininal Nutrition Suzuka University Of Medical Science
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Fujino Hidemi
Department Of Physical Therapy Faculty Of Health Care Science Himeji Dokkyo University
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Fujita Naoto
Department Of Pediatrics Hiroshima Red Cross Hospital
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Kondo Hiroyo
Department of Food Sciences and Nutrition, Nagoya Women's University
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Fujita Naoto
Department of Rehabilitation Science, Kobe University, Graduate School of Health Sciences
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Al-Nassan Saad
Department of Rehabilitation Science, Kobe University, Graduate School of Health Sciences
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