The effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome.
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概要
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Skeletal muscles in animals with metabolic syndrome exhibit reduced oxidative capacity. We investigated the effects of running exercise on fiber characteristics, oxidative capacity, and mRNA levels in the soleus muscles of rats with metabolic syndrome [SHR/NDmcr-cp (cp/cp); CP]. We divided 5-week-old CP rats into non-exercise (CP) and exercise (CP-Ex) groups. Wistar-Kyoto rats (WKY) were used as the control group. CP-Ex rats were permitted voluntary exercise on running wheels for 10 weeks. Triglyceride levels were higher and adiponectin levels lower in the CP and CP-Ex groups than in the WKY group. However, triglyceride levels were lower and adiponectin levels higher in the CP-Ex group than in the CP group. The soleus muscles in CP-Ex rats contained only high-oxidative type I fibers, whereas those in WKY and CP rats contained type I, IIA, and IIC fibers. Muscle succinate dehydrogenase (SDH) activity was higher in the CP-Ex group than in the CP group; there was no difference in SDH activity between the WKY and CP-Ex groups. Muscle proliferator-activated receptor γ coactivator-1α (PGC-1α) mRNA levels were higher in the CP-Ex group than in the CP group; there was no difference in PGC-1α mRNA levels between the WKY and CP-Ex groups. In CP-Ex rats, longer running distance was associated with increased muscle SDH activity and PGC-1α mRNA levels. We concluded that running exercise restored decreased muscle oxidative capacity and PGC-1α mRNA levels and improved hypertriglyceridemia in rats with metabolic syndrome.
- 2012-03-01
著者
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Takeda Isao
Department Of Physical Therapy Faculty Of Health Care Science Himeji Dokkyo University
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Nagatomo Fumiko
Laboratory Of Neurochemistry Graduate School Of Human And Environmental Studies Kyoto University
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TSUDA Kinsuke
Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University
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石原 昭彦
Laboratory Of Neurochemistry Graduate School Of Human And Environmental Studies Kyoto University
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Nagatomo Fumiko
京都大学 人間･環境学研究科認知･行動科学
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Ishihara Akihiko
Second Department Of Internal Medicine The University Of Tokushima
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Ishihara Akihiko
Laboratory Of Neurochemistry Faculty Of Integrated Human Studies Kyoto University
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Gu Ning
Laboratory Of Metabolism Graduate School Of Human And Environmental Studies Kyoto University
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Kondo Hiroyo
Department Of Food Science And Nutrition Nagoya Women's University
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Kondo Hiroyo
Department Of Clininal Nutrition Suzuka University Of Medical Science
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Fujino Hidemi
Department Of Rehabilitation Science Kobe University Graduate School Of Health Sciences
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Tsuda Kinsuke
Laboratory Of Metabolism Graduate School Of Human And Environmental Studies Kyoto University
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Fujino Hidemi
Division Of Rehabilitation Sciences Kobe University Graduate School Of Health Sciences
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Fujino Hidemi
Department Of Physical Therapy Faculty Of Health Care Science Himeji Dokkyo University
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Takeda Isao
Department Of Gastroenterology Ogaki Municipal Hospital
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Gu Ning
Department Of Life Science And Engineering Harbin Institute Of Technology
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Kouzaki Motoki
Laboratory Of Neurophysiology Graduate School Of Human And Environmental Studies Kyoto University
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Nagatomo Fumiko
Laboratory Of Cell Biology And Life Science Graduate School Of Human And Environmental Studies Kyoto University
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Ishihara Akihiko
Laboratory Of Cell Biology And Life Science Graduate School Of Human And Environmental Studies Kyoto University
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