Immunohistochemical Classification of Skeletal Muscle Fibers
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概要
- 論文の詳細を見る
Mammalian skeletal muscle fibers have several types of myosin heavy chain (MHC) isoforms. Immunohistochemical techniques enable us to identify the MHC isoform type in a single muscle fiber, i.e., MHCI, MHCIIa, MHCIIx, or MHCIIb. In addition, hybrid single fibers having more than one MHC isoform type can be classified using immuno-histochemistry. The presence of different MHC isoform(s) in a single fiber correlates with the maximal contractile velocity and the enzyme histochemical reaction of the myofibrillar adenosine triphosphatase. The adaptive response of the skeletal muscle is the basis of the fiber-type transformation depending on the phenotypic expression pattern in several MHC isoforms. In this review article, we address the availability of the monoclonal antibodies which recognize specific MHC isoform(s) in a single fiber.
- 日本組織細胞化学会の論文
著者
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KOBAYASHI Shigeo
Department of Applied Chemistry and Biochemistry, Kyushu Sangyo University
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ISHIHARA Akihiko
Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University
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Ibata Yasuhiko
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Ibata Yasuhiko
Department Of Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
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Kobayashi Shigeo
Department Of Applied Chemistry And Biochemistry Kyushu Sangyo University
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Ishihara Akihiko
Laboratory Of Neurochemistry Faculty Of Integrated Human Studies Kyoto University
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Hori Aiko
Department of Bio-informatics, Graduate School of Informatics
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Hori Aiko
Department Of Bio-informatics Graduate School Of Informatics
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Kobayashi Shigeo
Department Of Bio-informatics Graduate School Of Informatics
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Ishihara Akihiko
Laboratory Of Cell Biology And Life Science Graduate School Of Human And Environmental Studies Kyoto University
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