Radiation Biology of Caenorhabditis elegans : Germ Cell Response, Aging and Behavior

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概要

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• The study of radiation effect in Caenorhabditis (C.) elegans has been carried out over three decades and now allow for understanding at the molecular, cellular and individual levels. This review describes the current knowledge of the biological effects of ionizing irradiation with a scope of the germ line, aging and behavior. In germ cells, ionizing radiation induces apoptosis, cell cycle arrest and DNA repair. Lots of molecules involved in these responses and functions have been identified in C. elegans, which are highly conserved throughout eukaryotes. Radiosensitivity and the effect of heavy-ion microbeam irradiation on germ cells with relationship between initiation of meiotic recombination and DNA lesions are discussed. In addition to DNA damage, ionizing radiation produces free radicals, and the free radical theory is the most popular aging theory. A first signal transduction pathway of aging has been discovered in C. elegans, and radiation-induced metabolic oxidative stress is recently noted for an inducible factor of hormetic response and genetic instability. The hormetic response in C. elegans exposed to oxidative stress is discussed with genetic pathways of aging. Moreover, C. elegans is well known as a model organism for behavior. The recent work reported the radiation effects via specific neurons on learning behavior, and radiation and hydrogen peroxide affect the locomotory rate similarly. These findings are discussed in relation to the evidence obtained with other organisms. Altogether, C. elegans may be a good "in vivo" model system in the field of radiation biology.

• 2010-03-16

著者

• Ishioka N

  Iss Science Project Office Institute Of Space And Astronautical Science Japan Aerospace Exploration

• Ishii Naoaki

  Department Of Molecular Life Science Tokai University School Of Medicine

• Ishioka Noriaki

  奈良県立医科大学 生物学

• Ishioka Noriaki

  National Space Development Agency Of Japan

• Ishioka Noriaki

  京都工芸繊維大学 工芸科学部応用生物学

• 木梨 友子

  京都大学原子炉実験所附属粒子線腫瘍学研究センター

• Kinashi Yuko

  Radiation Safety And Control Research Reactor Institute Kyoto University

• SAKASHITA Tetsuya

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• KOBAYASHI Yasuhiko

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency

• Yamashita Shunichi

  Atomic Bomb Disease Institute Graduate School Of Biomedical Sciences Nagasaki University

• Ito Nobuhiko

  Laboratory Of Veterinary Radiology And Radiation Biology Department Of Veterinary Medicine Kitasato

• Kinashi Yuko

  Radiation Oncology Research Laboratory Research Reactor Institute Kyoto University

• KAGAWA Yasuhiro

  The Institute of Physical and Chemical Research

• TAKANAMI Takako

  Graduate School of Life Sciences, Tohoku University

• YANASE Sumino

  School of Sports and Health Science, Daito Bunka University

• HAMADA Nobuyuki

  Space Radiation Research Unit, International Open Laboratory, National Institute of Radiological Sci

• SUZUKI Michiyo

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency

• KIMURA Takafumi

  Graduate School of Life Sciences, Tohoku University

• HIGASHITANI Atsushi

  Graduate School of Life Sciences, Tohoku University

• SUZUKI Masao

  Natl Inst Radiol Sci

• HIGASHIBATA Akira

  Japan Aerospace Exploration Agency (JAXA)

• Ishioka Noriaki

  Space Utilization Research Center National Space Development Agency Of Japan (nasda)

• Ishioka Noriaki

  Department Of Space Environmental Medicine Kagoshima University Graduate School Of Medical And Denta

• Hamada Nobuyuki

  Space Radiation Research Unit International Open Laboratory National Institute Of Radiological Scien

• Kobayashi Yasuhiko

  Microbeam Radiation Biology Group Japan Atomic Energy Agency

• Sakashita Tetsuya

  Microbeam Radiation Biology Group Japan Atomic Energy Agency

• Yamashita Shunichi

  Nagasaki Prefectural Institute For Environmental Research And Public Health

• Ishioka Noriaki

  Department Of Molecular Life Science Tokai University School Of Medicine

• Suzuki Masao

  Microbeam Radiation Biology Group Japan Atomic Energy Agency

• Kinashi Yuko

  Kyoto Univ. Research Rcactor Institute

• Ishii Naoaki

  Department Of Molecular Biology School Of Medicine Tokai University

• Yanase Sumino

  School Of Sports And Health Science Daito Bunka University

• Higashibata Akira

  Kagoshima University Graduate School Of Medical And Dental Sciences Space Environmental Medicine

• Higashitani Atsushi

  Graduate School Of Life Sciences Tohoku Univ.

• Kimura Takafumi

  Graduate School Of Life Sciences Tohoku Univ.

• Kimura Takafumi

  Graduate School Of Life Sciences Tohoku University

• Higashibata Akira

  Space Utilization Research Center National Space Development Agency Of Japan (nasda)

• Takanami Takako

  Graduate School Of Life Sciences Tohoku Univ.

• Suzuki Michiyo

  Microbeam Radiation Biology Group Japan Atomic Energy Agency

• Higashibata Akira

  Graduate School Of Life Sciences Tohoku University

• Hamada Nobuyuki

  Radiation Safety Research Center Nuclear Technology Research Laboratory Central Research Institute Of Electric Power Industry

• Kobayashi Yasuhiko

  Advanced Science Research Center Japan Atomic Energy Research Institute

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