The Role of Mitochondrial Superoxide Anion (O_2^-) on Physiological Aging in C57BL/6J Mice
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概要
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Much attention has been focused on the mitochondrial superoxide anion (O_2^-), which is also a critical free radial produced by ionizing radiation. The specific role of the mitochondrial O_2^- on physiological aging in mammals is still unclear despite wide-spread evidence that oxidative stress is involved in aging and age-related diseases. The major endogenous source of O_2^- is generated as a byproduct of energy metabolism from mitochondria. In order to better understand how O_2^- relates to metazoan aging, we have comprehensively examined age-related changes in the levels of oxidative damage, mitochondrial O_2^- production, mitochondrial antioxidant enzyme activity and apoptosis induction in key organs of an inbred mouse strain (C57BL/6J). Oxidative damage accumulated and excess apoptosis occurred in the brain, oculus and kidney with aging, but comparatively little occurred in the heart and muscle. These rates are correlated with O_2^- levels. Mitochondrial O_2^- production levels increased with aging in the brain, oculus and kidney, and did not significantly increased in the heart and muscle. In contrast to O_2^- production, mitochondrial SOD activities increased in heart and muscle, and remained unchanged in the brain, oculus and kidney with aging. These results suggest that O_2^- production has high organ specificity, and oxidative damage by O_2^- from mitochondria mediated apoptosis can lead to organ atrophy and physiological dys-function. In addition, O_2^- from mitochondria plays a core role in physiological aging.
- 日本放射線影響学会の論文
- 2009-01-16
著者
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Miyazawa Masaki
Department of Pathology, Tokai University School of Medicine
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Ishii Naoaki
Department Of Molecular Life Science Tokai University School Of Medicine
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Hartman Philp
Biology Department Texas Christian University
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Miyazawa Masaki
Department Of Molecular Life Science Tokai University School Of Medicine
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Miyazawa Masaki
Department Of Immunology Kinki University School Of Medicine
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Yasuda Kayo
Teaching And Research Support Center Tokai University School Of Medicine
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Yasuda Kayo
Department Of Dermatology Kochi Medical School
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Ishii Naoaki
Department Of Molecular Biology School Of Medicine Tokai University
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Ishii Takamasa
Department Of Molecular Life Science Tokai University School Of Medicine
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NODA Setsuko
Department of Nursing, Tokai University School of Health Science
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Noda Setsuko
Department Of Nursing Tokai University School Of Health Science
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Noda Setsuko
Department Of Anatomy School Of Medicine Tokai University
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ONOUCHI Hiromi
Department of Ophthalmology, Tokai University School of Medicine
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HARTMAN Philip
Department of Biology, Texas Christian University
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Onouchi Hiromi
Department Of Ophthalmology Tokai University School Of Medicine
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Hartman Philip
Department Of Biology Texas Christian University
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