Effect of 5-Fluorodeoxyuridine on Reproduction and Aging in a Strain of Free-living Nematodes, Rhabditidae tokai
スポンサーリンク
概要
- 論文の詳細を見る
To obtain age-synchronized populations of a strain of free-living nematodes, Rhabditidae tokai, effects of 5-deoxyuridine on reproduction and age-related survival were investigated. The following results were obtained. (1) Eggs and early larvae were much more sensitive to this drug than late larve or adults with respect to the killing effect. (2) At low concentrations (10^<-5> to 10^<-4> M), where no significant killing effect was observed, 5-deoxyuridine did not inhibit egg production, but the eggs produced in the presence of the drug were almost unhatchable. (3) In long-range observations, it was found that 5-deoxyuridine reduced significantly the life span of the nematode. It was concluded that 5-deoxyuridine is not an adequate inhibitor of reproduction in aging research, while the results postulated an interesting problem concerning egg formation or fertilization.
- 東海大学の論文
著者
-
Ishii Naoaki
Department Of Molecular Biology School Of Medicine Tokai University
-
Suzuki Kenshi
Department Of Hematology Japanese Red Cross Medical Center
-
MORIYA Yoko
Department of Molecular Biology, School of Medicine, Tokai University
-
Moriya Yoko
Department Of Molecular Biology School Of Medicine Tokai University
関連論文
- Radiation Biology of Caenorhabditis elegans : Germ Cell Response, Aging and Behavior
- Phase II and pharmacokinetic study of thalidomide in Japanese patients with relapsed/refractory multiple myeloma
- Locomotion - Learning Behavior Relationship in Caenorhabditis elegans Following γ-Ray Irradiation
- Plasma concentration of micafungin in patients with hematologic malignancies
- A low cost and quick assay system using the free-living nematode Caenorhabditis elegans to determine the effects of Kampo medicines on life span
- Post-dauer Life Span of Caenorhabditis Elegans Dauer Larvae Can be Modified by X-irradiation
- Post-dauer Life Span of Caenorhabditis Elegans Dauer Larvae Can be Modified by X-irradiation
- Hyperoxia Exposure Induced Hormesis Decreases Mitochondrial Superoxide Radical Levels via Ins/IGF-1 Signaling Pathway in a Long-lived age-1 Mutant of Caenorhabditis elegans
- Phenotypic Properties of C. elegans Defective in Uracil-DNA Glycosylase Activity
- Cloning and Characterization of Uracil-DNA Glycosylase Gene of Caenorhabditis elegans
- The Role of Mitochondrial Superoxide Anion (O_2^-) on Physiological Aging in C57BL/6J Mice
- Fidelity of DNA Polymerase α Partially Purified from a Mutator Mutant and Wild-Type Mouse FM3A Cells
- Inhibition in Maturation of Nascent DNA Fragments in Cultured Mouse FM3A Cells after Treatment with DNA-Damaging Agents
- Light-and Electron Microscopic Observations of a Strain of Free-living Nematodes, Rhabditidae tokai
- Effect of Near Ultraviolet Light on Escherichia coli Sensitized with 8-Methoxypsoralen : Mutagenic Effect and Induction of Lambda Prophage
- Suppression of Deoxyguanosine Cytotoxicity and Deoxyguanosine Kinase Activity in Mouse FM3A Mammary Carcinoma Cell : Mutants Defective in Hypoxanthine Phosphoribosyl-transferase
- Oxygen-Sensitive Mutants of the Nematode Caenorhabditis Elegans and Aging(The 4th Joint Symposium between Tokai University School of Medicine and Semmelweis University School of Medicine 7-9, June, 1993, Budapest)
- Avian Malaria-like Disease Found in Young Cranes : Grus monacha
- Molecular Mechanism of Life Span Deteminatio
- Type AB thymoma accompanied by pure red cell aplasia and Good syndrome with CMV infection of tumor cells
- Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases : a multi-institutional study
- Cloning of the Oxidative Stress-responsive Genes in Caenorhabditis elegans
- Follicular lymphoma with marked infiltration of eosinophils
- Effect of 5-Fluorodeoxyuridine on Reproduction and Aging in a Strain of Free-living Nematodes, Rhabditidae tokai
- Comparison of Argininosuccinate Synthetase from Young and Old Rat Livers
- Prolonged low-dose administration of the cyclooxygenase-2 inhibitor celecoxib enhances the antitumor activity of irinotecan against neuroblastoma xenografts
- Repair of Genetic Material and Related Problems : a review
- Inhibitory Effect of Hydroquinone and Related Agents on Multiplicity Reactivation and Genetic Recombination of Bacteriophage T4
- Evaluation of the risk factors for febrile neutropenia associated with hematological malignancy
- Life-threatening hemorrhagic shock after laparoscopic surgery : a case of postoperative thrombotic thrombocytopenic purpura
- Diagnosis and treatment of multiple myeloma and AL amyloidosis with focus on improvement of renal lesion