Long Term Prognostic Implications of Expression of Glucose Transporter-1 and Hexokinase II in Patients with Stage I Uterine Leiomyosarcoma
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概要
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Many malignant epithelial tumors show increased expression of glucose transporter-1 (GLUT-1) and hexokinase II (HK-II), both of which are involved in glucose metabolism. GLUT-1 levels are often correlated with prognosis in these tumors. The current retrospective study was conducted to evaluate the importance of GLUT-1 and HK-II expression in leiomyosarcoma (LMS), a malignant uterine non-epithelial tumor with a poor prognosis. The subjects were 23 patients with stage I LMS. Expression of GLUT-1 and HK-II was evaluated immunohistochemically in samples removed surgically, and the MIB-1 index was evaluated as a measure of cell proliferation. The association of these results with prognosis was examined. Twenty samples of leiomyoma (LOM), a benign non-epithelial tumor, were used as controls. Immunohistochemical expression was defined as negative staining (–), weak to sporadic staining (1+), and strong staining (2+) per microscopic field, respectively. Malignancy was evaluated in 2000 cells and the MIB-1 index was calculated. Overall survival for LMS was estimated using the Kaplan-Meier method. Of the LMS cases, 12 were GLUT-1-positive (52.2%; 2+: 2, 1+: 10) and 15 were HK-II-positive (65.2%; 2+: 1, 1+: 14). GLUT-1 expression in LMS was significantly correlated with the MIB1 index. The 10-year survival rates were 90.9% and 58.3% in GLUT-1-negative and GLUT-1-positive cases, respectively, and 75.0% and 73.3% in HK-II-positive and HK-II-negative cases, respectively. GLUT-1 expression was significantly correlated with prognosis. Cases of stage I LMS showed a significant correlation between the expression level of GLUT-1 and the MIB-1 index, an indicator of malignancy. GLUT-1-negative cases had a better prognosis than GLUT-1-positive cases, suggesting that GLUT-1 expression is an effective prognostic marker.
著者
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Iida Tetsuji
Department of Obstetrics and Gynecology, Tokai University School of Medicine
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Mikami Mikio
Department of Obstetrics and Gynecology, Tokai University School of Medicine
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Iida Tetsuji
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Mikami Mikio
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Tsukada Hitomi
Department of Obstetrics and Gynecology, Tokai University School of Medicine
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Muramatsu Toshinari
Department Of Obstetrics And Gynecology School Of Medicine Tokai University
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Miyazawa Masaki
Department Of Immunology Kinki University School Of Medicine
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Hirasawa Takeshi
Department Of Obstetrics And Gynecology Tokai University School Of Medicine
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Shida Masako
Department Of Obstetrics And Gynecology Center For Growth And Reproductive Medicine Tokai University
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Ikeda Masae
Department Of Gynecology Kanagawa Cancer Center Hospital
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Murakami Masaru
Department Of Cardiology Tokushima Prefectural Central Hospital
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Kajiwara Hiroshi
Department Of Neurosurgery Teikyo University Chiba Medical Center
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Yasuda Masanori
Department Of Neurosurgery Nippon Medical School
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Murakami Masaru
Department of Obstetrics and Gynecology, Tokai University Oiso Hospital
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Ikeda Masae
Department of Cardiovascular Medicine, National Hospital Organization Fukuyama Medical Center
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Ikeda Masae
Department of Obstetrics and Gynecology, Tokai University School of Medicine
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