Expression of Bone Matrix Proteins in Malignant Myoepithelioma with Extensive Osteoid Formation Occurring in The Maxilla
スポンサーリンク
概要
- 論文の詳細を見る
We report here a rare case of malignant myoepithelioma occurring in the maxilla, accompanied by extensive osteoid formation. The patient was a 20-year-old Japanese man with a rapidly swelling mass in the hard palate. Expressions of bone sialoprotein (BSP) and osteopontin (OPN) were examined by immunohistochemistry, in situ hybridization (ISH) and RT-PCR. The mass showed invasive growth of atypical spindle and polygonal cells with abundant osteoid tissue in the stroma. These cells retained immunohistochemical features of myoepithelium, characterized by positive reactivity for cytokeratin (WS), cytokeratin 14, S-100 protein, vimentin, smooth muscle myosin heavy chain and calponin. In addition, malignant myoepithelium noted in and around the osteoid tissue showed expression of BSP on immunohistochemical analysis and ISH, but with no expression of OPN. The normal salivary gland tissue was negative for BSP and OPN. These results suggested that BSP might play a significant role in osteoid development in the present case.
- 特定非営利活動法人日本臨床口腔病理学会の論文
- 2003-06-25
著者
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OSAMURA R.
Department of Pathology, Tokai University School of Medicine
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Yasuda Masanori
Department of Pathology, Saitama Medical University International Medical Center
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Osamura R
Department Of Pathology Tokai University School Of Medicine
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Osamura R.yoshiyuki
東海大学 医学研究科病理病態学
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Osamura Yoshiyuki
東海大学 医学研究科病理病態学
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Osamura R.yoshiyuki
東海大学 医学部病理診断学
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Osamura R
東海大学 医学研究科病理病態学
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Osamura R.yoshiyuki
東海大学教育･研究支援センター
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Osamura Robert
Dep. Of Pathology Tokai Univ. School Of Medicine
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Osamura R.
Department Of Pathology School Of Medicine Tokai University
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WATANABE Yoshihisa
Department of Surgery, Division II, Kobe University School of Medicine
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Tsukinoki Keiichi
Department of Pathology, Kanagawa Dental College
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Sato Sadao
Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College
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KARAKIDA Kazunari
Departments of Oral Surgery Tokai University School of Medicine
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OTA Yoshihide
Departments of Oral Surgery Tokai University School of Medicine
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Sasaguri Keniich
Department of Orthodontics, Kanagawa Dental College
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Yasuda M
Department Of Pathology Tokai University School Of Medicine
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Yasuda Masanori
Department Of Pathology School Of Medicine Tokai University
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Yasuda Masanori
Departments Of Pathology Tokai University School Of Medicine
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Watanabe Yoshihisa
Department Of Maxillofacial Diagnostic Science Division Of Pathology Kanagawa Dental College
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Osamura R
Tokai Univ. School Of Medicine Kanagawa Jpn
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Sato Sadao
Department Of Craniofacial Growth And Development Dentistry Kanagawa Dental College
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Ota Yoshihide
Department Of Oral Surgery School Of Medicine Tokai University
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Watanabe Y
Department Of Oral Pathology Kanagawa Dental College
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Osamura R.
Tokai Univ. School Of Medicine Kanagawa Jpn
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Yamazaki Michio
Department Of Pathology Saitama Medical University International Medical Center
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Karakida Kazunari
Department Of Oral And Maxillofacial Surgery Tokai University Hachioji Hospital
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Sasaguri Keniich
Department Of Orthodontics Kanagawa Dental College
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Mizoguchi Yoshikazu
Department Of Maxillofacial Diagnostic Science Division Of Pathology Kanagawa Dental College
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Marugami Yoshihisa
Department Of Pathology Fujita Health University School Of Medicine
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Yasuda Mitsuhiro
Department Of General Surgery Fukuoka Dental College Hospital
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Karakida Kazunari
Department Of Oral Surgery Tokai University Hachioji Hospital
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Tsukinoki K
Department Of Maxillofacial Diagnostic Science Division Of Pathology Kanagawa Dental College
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Osamura R.yoshiyuki
Dept Of Pathology Tokai Univ School Of Medicine
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Watanabe Yoshihisa
Department Of Community Health Tokai University School Of Medicine
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Tsukinoki Keiichi
Department Of Oral Pathology Kanagawa Dental College
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Yasuda Masanori
東海大学 医学部病理学
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Yasuda Masanori
Department Of Pathology Saitama Medical University International Medical Center
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Yasuda Masanori
Department Of Neurosurgery Nippon Medical School
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Ota Yoshihide
Department Of Oral And Maxillofacial Surgery Tokai University School Of Medicine
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Watanabe Yoshihisa
Department Of Basic Geriatrics Graduate School Of Medical Science Kyoto Prefectural University Of Medicine
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Tsukinoki Keiichi
Department of Environmental Pathology and Research Institute of Salivary Gland Health Medicine, Kanagawa Dental College Postgraduate School
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TSUKINOKI Keiichi
Department of Diagnostic Science Division of Pathology, Kanagawa Dental College
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