Expression of Transcriptional Factors of GATA4, GATA6 and SF-1 in the Developmental Process of Rat Adrenal Cortex; the Possible Contribution of GATA4 in Limited Expression before Zonal Establishment
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概要
- 論文の詳細を見る
The adrenal cortex consists of three zones producing different hormones : zona glomerulosa (zG), zona fasciculata (zF) and zona reticularis (zR). Accumulated knowledge has revealed the contribution of transcriptional factors to the functional development of the adrenal cortex, however, the regulatory mechanisms have not yet been fully understood. We studied the expression and localization of transcriptional factors, SF-1, GATA4 and GATA6 by immunohistochemistry in the developmental process, establishing three zones of the rat adrenal cortex. The development of the adrenal cortex was monitored by the expression of cortical enzymes, P45011p, P450aldo, and P450scc on gestational days 15, 16, 18, 19, 20 (G15, G16, G18, G19, G20) and postnatal days 1, 2, 20 (P1, P2, P20) in Spraque-Dawley rats. GATA4 expression was observed in a limited number of cortical cells from early gestation (G15) to the neonatal period (P20) before complete establishment of the cortical zones. Nearing the final phase of zG establishment (P20), GATA4 changed its intracellular localization from the nuclei to the perinuclear region. Another noteworthy finding is that GATA6 translocated from the cytoplasm into the nuclei on G19, followed by a leaning distribution of SF-1 in zG (P1) and changing the distribution of SF-1 from zG to zF parallel to the establish ment of zG (P20). In conclusion, we report that GATA4 was detected in the immature phase of the adrenal cortex in limited expression but diminished in the mature adrenal cortex. GATA4 may participate in the gene transcription required for the development of the adrenal cortex.
- 日本組織細胞化学会の論文
著者
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OSAMURA R.
Department of Pathology, Tokai University School of Medicine
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Umemura Shinobu
Department of Pathology, Tokai University School of Medicine
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SHINOHARA OSAMU
Department of Pediatrics, Tokai University School of Medicine
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TOMITA Yuichiro
Department of Pediatrics, Tokai University School of Medicine
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MITANI Fumiko
Department of Biochemistry, School of Medicine, Keio University
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Osamura R.yoshiyuki
東海大学 医学研究科病理病態学
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Osamura Yoshiyuki
東海大学 医学研究科病理病態学
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Osamura R.yoshiyuki
東海大学 医学部病理診断学
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Osamura R
東海大学 医学研究科病理病態学
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Osamura R.yoshiyuki
東海大学教育･研究支援センター
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Osamura Robert
Dep. Of Pathology Tokai Univ. School Of Medicine
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Osamura R.
Department Of Pathology School Of Medicine Tokai University
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Mitani Fumiko
Department Of Biochemistry Keio University School Of Medicine
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ICHIKAWA Iekuni
Department of Bioethics, Tokai University School of Medicine
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Hasegawa Hideaki
Department of Pathology and Labolatories of Structure and Function Research
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Tomita Yuichirou
Department Of Pediatrics Tokai University School Of Medicine
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Tomita Yuichiro
Department Of Pediatrics For Structure And Function Research Tokai University School Of Medicine
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Shinohara Osamu
Department Of Pediatrics Tokai University School Of Medicine
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Shinohara Osamu
Department Of Pediatrics Faculty Of Medicine Tokai University
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Hasegawa H
Laboratory Of Structure And Function Research Tokai University School Of Medicine
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Osamura R.
Tokai Univ. School Of Medicine Kanagawa Jpn
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Umemura S
Department Of Pathology Tokai University School Of Medicine
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Umemura Shinobu
Department Of Pathology & Division Of Diagnostic Pathology Tokai University School Of Medicine
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Ichikawa I
Tokai Univ.
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Ichikawa Iekuni
Department Of Bioethics Tokai University School Of Medicine
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Osamura R
Tokai Univ. School Of Medicine
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Osamura R.yoshiyuki
Dept Of Pathology Tokai Univ School Of Medicine
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Umemura S
Tokai Univ. School Of Medicine
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TOMITA Yuichiro
Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
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TOMITA Yuichiro
Department of Animal Science, Faculty of Agriculture, Kagoshima University
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