RNA tumor virus-like particles in thymus cells of patients with myasthenia gravis.
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概要
- 論文の詳細を見る
We report here the appearance of retrovirus-like particles in cultured thymus cells from patients with myasthenia gravis. Cell from five patients with myasthenia gravis were examined. Histologically three were thymomas and two were thymus hyperplasias. The thymus cells were co-cultured for 7 days with allogenic B cells pretreated with mitomycin C. Retrovirus-like particles were demonstrated by electron microscopy in 4 cases of myasthenia gravis. These particles were detected in thymus epithelial cells. In 4 cases of myasthenia gravis examined, reverse transcriptase activity sedimenting at a density of 1.15-1.17 g/cm3 in sucrose density gradients was eluted in the culture fluids. These results suggest that in myasthenic thymuses, retroviruses that can be induced, following a proliferative stimulus, may be involevd in the genesis of thymic disorders, and in the pathogenesis of myasthenia gravis.
- The Keio Journal of Medicineの論文
著者
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Saito Hidetsugu
Department Of Internal Medicine Division Of Gastroenterology Keio University School Of Medicine
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Higashinakagawa Toru
Department Of Biology School Of Education Waseda University
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Tsuchiya Masaharu
Department Of Internal Medicine Keio University
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Kondo Shunzo
Mitsubishi Kagaku Inst. Of Life Sci. Tokyo Jpn
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Murakami Masaru
Department Of Cardiology Tokushima Prefectural Central Hospital
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Nakamura Tatsuya
Department Of Anatomy Kitasato University School Of Medicine
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Ono Akira
Department of 2nd Internal Medicine, Faculty of Medicine, Oaka University
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YOSHIMATSU HIROSHI
Department of Internal Medicine and Surgery, University of Occupational and Environmental Health
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KONDO SHUNZO
Mitsubishi-Kasei Institute of Life Sciences
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SUZUKI HIDERO
Department of Internal Medicine and Surgery, University of Occupational and Environmental Health
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