Studies on the difference of lymphatic absorption between saturated and unsaturated long chain fatty acids in rats - Particularly in reference with the effect of puromycin and colchicine.:PARTICULARLY IN REFERENCE WITH THE EFFECT OF PUROMYCIN AND COLCHICI

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The present studies were carried out to assess the metabolic differences between saturated and unsaturated long chain fatty acids in the process of lipid absorption and transportation to lymphatics. Male Wistar rats provided with intestinal lymph fistula were used for this experiment. Mixed micellar solutions of linoleic acid (18-carbon, unsaturated) or palmitic acid (16-carbon, saturated) were administered intraduodenally with labelled fatty acids ([1-14C] linoleate or [1-14C] palmitate) and absorbed fats were determined as the values for radioactivity of these two fatty acids found in intestinal lymph.The absorption and transportation of linoleic acid into intestinal lymph exceeded those of palmitic acid. Puromycin, an inhibitor of protein synthesis resulting in the block of lipoprotein formation of intestinal absorptive cells, decreased the lymphatic absorption of linoleic acid, whereas not significantly decreased that of palmitic acid. It is conceivable that puromycin will mainly inhibit the formation of chylomicron rich lipoprotein from linoleic acid and that the phase of lipoprotein formation will be atttributable to the difference of absorption of these two long chain fatty acids. Colchicine, an inhibitor of microtubular function of intestinal cells which may block the release of synthe-sized lipoprotein out of cells, caused a delayed and decreased lymphatic ab-sorption and transportation of palmitic acid as well as linoleic acid. Therefore we considered that there was no significant difference between two fatty acids in the phase of lipoprotein secretion.
The Keio Journal of Medicineの論文

Studies on the difference of lymphatic absorption between saturated and unsaturated long chain fatty acids in rats - Particularly in reference with the effect of puromycin and colchicine.:PARTICULARLY IN REFERENCE WITH THE EFFECT OF PUROMYCIN AND COLCHICI

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