Effects of reduced glutathione on experimental hemorrhagic shock.
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概要
- 論文の詳細を見る
Effects of reduced glutathione (GSH) were evaluated in animals sub-jected to hemorrhagic shock. In this study using rabbits, three phases were shown in the pattern of bleeding, i.e., bleeding phase, quiescent phase and reflux phase with resultant animals' death. We observed marked disturbance in the levels of histamine during the course of hemorrhage. Administration of GSH abolished reflux phase, indicating well maintained vascular tone, and an exaggerated release of plasma histamine was significantly suppressed. In rats, microcirculatory disorders as well as the degranulation rate of mast cells in the mesentery were significantly prevented by the administration of GSH. Thus GSH seems to exert salutary effects on hemorrhagic shock primarily by the maintenance of vascular tone and suppression of the release of chemical mediators.
- The Keio Journal of Medicineの論文
著者
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Suzuki Osamu
Department Of Cardiology Iwate Prefectural Iwai Hospital
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Ishii Kohdoh
Department Of Internal Medicine National Minami Yokohama Hospital
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Tsuchiya Masaharu
Department Of Internal Medicine Keio University
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Maruyama Katsuya
Department Of Internal Medicine Kurihama National Hospital
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Nagata Hiroshi
Department Of Internal Medicine And Pathology School Of Medicine Keio University
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MARUYAMA KATSUYA
Department of Internal Medicine School of Medicine, Keio University
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ISHII KOHDOH
Department of Internal Medicine, School of Medicine, Kitasato University
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FUJIHIRO YASUO
Surgery School of Medicine, Keio University
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NAGATA HIROSHI
Department of Internal Medicine School of Medicine, Keio University
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