Contribution of Translin to Hematopoietic Regeneration after Sublethal Ionizing Irradiation(Highlighted paper selected by Editor-in-chief,Molecular and Cell Biology)
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概要
- 論文の詳細を見る
The integrity of the genome is threatened by DNA damaging events such as radiation, viral infection and chemicals. Ionizing irradiation is known to cause genotoxic damage through the generation of reactive oxygen species (ROS) and nitrogen species (RNS) and we have found that a signaling pathway for the nuclear translocation of Translin is initiated in association and efficiently blocked by a specific inhibitor of nitric oxide synthase (NOS). This suggests the involvement of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) in the nuclear translocation of Translin. To address the functional significance of Translin in the hematopoietic generation system after ionizing irradiation, we generated Translin-deficient (Translin^<-/->) mice and examined hematopoietic colony formation after sublethal ionizing irradiation. We thereby confirmed a severe delay of colony formation in the spleens of Translin^<-/-> as compared with Translin^<+/+> mice. Taken together, the results suggest that Translin contributes to hematopoietic regeneration by acting as a sensor protein for radiation-induced damage.
- 公益社団法人日本薬学会の論文
- 2008-02-01
著者
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鈴木 修
池浦特許事務所
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Fukuda Yuko
Department of Cardiovascular Medicine, Kobe University Graduate School of Medicine
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Aoki Katsunori
国立感染症研究所 免疫部
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Aoki Katsunori
Department Of Hematology (internal Medicine) The University Of Tokyo
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Aoki Katsunori
Department Of Cell Therapy & Transplantation Medicine University Of Tokyo Hospital
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SUZUKI Osamu
Department of Fermentation Technology, Hiroshima University
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Suzuki O
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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Suzuki Osamu
Department Of Cardiology Iwate Prefectural Iwai Hospital
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Suzuki O
Department Of Legal Medicine Hamamatsu University School Of Medicine
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Mochida K
Bioresource Center Riken
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Mochida Keiji
Department Of Veterinary Science National Institute Of Infectious Diseases
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KASAI Masataka
Department of Immunology, National Institute of Infectious Diseases
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Nakahara Kazuhiko
National Institution For Academic Degrees And University Evaluation
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Sato O
Second Department Of Surgery Faculty Of Medicine The University Of Tokyo
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Sato Osamu
東京大学 第2外科
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Suzuki O
Department Of Veterinary Science National Institute Of Infectious Diseases
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Suzuki O
Second Department Of Surgery Yamanashi Medical University
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Fukuda Yuko
Department Of Immunology National Institute Of Infectious Diseases
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Kasai Masataka
Department Of Immunology National Institute Of Infectious Diseases
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MATSUDA Junichiro
Department of Veterinary Science, National Institute of Infectious Diseases
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ISHIDA Reiko
Department of Immunology, National Institute of Infectious Diseases
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TAKASHI Tohru
New Product Research Laboratories III, Tokyo R&D Center, Daiichi Pharmaceutical Co., Ltd.
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MOCHIDA Keiji
Bioresource Center, RIKEN
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Ishida Reiko
Department Of Immunology National Institute Of Infectious Diseases
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Matsuda Junichiro
Department Of Veterinary Science National Institute Of Infectious Diseases
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Matsuda Junichiro
Department Of Veterinary Science National Institute Of Health
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Mochida Keiji
Bioresource Center Riken
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Takashi Tohru
New Product Research Laboratories Iii Tokyo R&d Center Daiichi Pharmaceutical Co. Ltd.
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Takashi Tohru
New Product Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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Nakahara Kazuhiko
National Food Research Institute Ministry Of Agriculture Forestry And Fisheries
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Suzuki Osamu
Department Of Veterinary Science National Institute Of Infectious Diseases
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