Toward Elucidating the Full Spectrum of Mite Allergens : State of the Art

概要

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Our research has focused on the molecular design of immunotherapeutic vaccines and the advancement of mite-allergy diagnosis. Here, we describe the research history of the major group 1 and group 2 allergens, immunoelectrophoretic analyses covering the complete spectrum of mite allergens, our results on allergens with distinctive characteristics (a conjunctival congestion-eliciting antigen [LM2], an immunotherapeutic antigen [HM2] with high efficacy and without definite adverse reactions, and a potent T-cell stimulatory antigen [HM1] with secretion of IFN-★), the full spectrum and immunochemical properties of the major and other important mite allergens (including our newly described allergens : a pan-allergen [tropomyosin, group 10], a potent T-cell stimulatory allergen [M-177, apolipophorin, group 14] and its peptide fragments Magi and Mag3, a moderate IgE-binding allergen [gelsolin/villin, group 16], an EF-hand Ca^<2+>-binding allergen [group 17], and a less IgE-binding allergen [heat shock protein 70]), and prospects for the development of immunotherapeutic and diagnostic agents.
社団法人日本生物工学会の論文
2002-10-25