Effect of Various Halide Salts on the Incompatibility of Cyanocobalamin and Ascorbic Acid in Aqueous Solution

スポンサーリンク

概要

• 論文の詳細を見る

• Combination of cyanocobalamin (VB12) and ascorbic acid (VC) has been widely seen in pharmaceutical products and dietary supplements. However, VB12 has been reported that its behavior in stability in aqueous solution is quite different when VC is mixed. In the present study, we examined the stabilities of these vitamins in acetate buffer (pH 4.8) using high performance liquid chromatography. Degradation of VB12 was not observed in the absence of VC in the buffer. However, when VC was mixed in the VB12 solution, VB12 concentrations decreased in accordance with VC degradation. VB12 and VC degradations were inhibited by adding sodium halides to acetate buffer at pH 4.8. These stabilization effects were also observed in the range from pH 3.5 to 5.3 and by adding potassium, magnesium, and calcium halides. Furthermore, our data demonstrated that increases in the halide anion concentrations and atomic number (Cl^-<Br^-<I^-) were proportionally associated with better stabilities of both VB12 and VC. Therefore, choosing an appropriate condition with a certain halide salt may be useful for stabilizing pharmaceutical products and dietary supplements when VB12 and VC are combined in solution.

• 公益社団法人日本薬学会の論文
• 2005-06-01

著者

• ONO Kazuhisa

  Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni

• ICHIKAWA Makoto

  Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd.

• Ichikawa M

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Ichikawa Makoto

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Ichikawa M

  Faculty Of Engineering Yamaguchi University

• Ono Kazuhisa

  Department Of Fermentation Technology Faculty Of Engineering Hiroshima University

• Ono Kazuhisa

  Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer

• IDE Nagatoshi

  Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd.

• SHIRAISHI Sumihiro

  Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd.

• Ide Nagatoshi

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Shiraishi Sumihiro

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

関連論文

• A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen
• Effects of a Fermented Barley Extract on Subjects with Slightly High Serum Uric Acid or Mild Hyperuricemia
• Effects of Single and Combined Administration of Fermented Barley Extract and γ-Aminobutyric Acid on the Development of Atopic Dermatitis in NC/Nga Mice
• Metabolism and synthesis of lipids in the polyunsaturated fatty acid-producing fungus Mortierella alliacea
• Simultaneous determination of seven saponins in the roots of Codonopsis lanceolata by liquid chromatography-mass spectrometry
• Rapid identification of triterpenoid saponins in the roots of Codonopsis lanceolata by liquid chromatography-mass spectrometry
• Codonopsis lanceolata Ameliorate Plasma Testosterone Reduction Induced by Immobilization Stress in Middle-Aged Mice
• Codonopsis lanceolata Accelerates Recovery from the Reproductive Dysfunction Induced by Hyperthermic Treatment in Male Mice
• Triterpene Glycosides from the Roots of Codonopsis lanceolata
• Metabolism and Synthesis of Lipids in the Polyunsaturated Fatty Acid-Producing Fungus Mortierella alliacea
• Effects of Fermented Barley Extract on Antioxidant Status in Mice
• Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation
• Purification and Characterization of a Novel Fungal α-Glucosidase from Mortierella alliacea with High Starch-hydrolytic Activity(Biochemistry & Molecular Biology)
• Realizing Visual Functions with the Reaction-Diffusion Mechanism
• Lipid Composition of a Newly Isolated Polyunsaturated Fatty Acid-Producing Fungus, Achlya sp.ma-2801
• Effect of Various Halide Salts on the Incompatibility of Cyanocobalamin and Ascorbic Acid in Aqueous Solution
• Pharmacokinetic Study of Allixin, a Phytoalexin Produced by Garlic
• HPLC Determination of (+)-Pseudoephedrine and (-)-Ephedrine in Japanese Herbal Medicines Containing Ephedra Herb Using Solid-Phase Extraction
• Toward Elucidating the Full Spectrum of Mite Allergens : State of the Art
• Nutritional Enrichment of Larval Fish Feed with Thraustochytrid Producing Polyunsaturated Fatty Acids and Xanthophylls(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Utilization of Shochu Distillery Wastewater for Production of Polyunsaturated Fatty Acids and Xanthophylls Using Thraustochytrid(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Effects of Novel Ethacrynic Acid Derivatives on Human Trabecular Meshwork Cell Shape, Actin Cytoskeletal Organization, and Transcellular Fluid Flow(Pharmacology)
• Effects of the New Ethacrynic Acid Derivative SA9000 on Intraocular Pressure in Cats and Monkeys(Pharmacology)
• New Ethacrynic Acid Derivatives as Potent Cytoskeletal Modulators in Trabecular Meshwork Cells(Medicinal Chemistry)
• Characterization of Ocular Pharmacokinetics of Tilisolol after Instillation into Anesthetized Rabbits
• Topical Delivery System of Ophthalimic Drugs by Periocular Injection with Viscous Solution
• Drug Absorption Behavior after Periocular Injections
• The effect of anti-histone H1 Ab on dendritic cells and natural killer cells during rejection phase in liver transplantation
• Dietary Pulverized Konjac Glucomannan Prevents the Development of Allergic Rhinitis-Like Symptoms and IgE Response in Mice
• In Vitro Characteristics and in Vivo Plasma Disposition of Cisplatin Conjugated with Oxidized and Dicarboxymethylated Dextrans
• SYNTHESIS OF VALPROYL-2-PYRROLIDINONE AND ITS EVALUATION AS A COGNITIVE DRUG WITH THE ABILITY TO MODULATE ACIDIC AMINO ACIDS IN THE BRAIN
• Determination of γ-Aminobutyric Acid and Associated Amino Acids in Mouse Brain by Liquid Chromatography
• Extracellular Secretion of Free Fatty Acids by Disruption of a Fatty Acyl-CoA Synthetase Gene in Saccharomyces cerevisiae
• Grouping Newly Isolated Docosahexaenoic Acid-Producing Thraustochytrids Based on Their Polyunsaturated Fatty Acid Profiles and Comparative Analysis of 18S rRNA Genes
• Induction of inducible nitric oxide synthase mRNA expression and nitric oxide production from macrophages stimulated with high-molecular size mite antigen HM1
• Evidence of Isozymes for Δ6 Fatty Acid Desaturase in Rat Hepatocytes(Biochemistry & Molecular Biology)
• Enzymatic Preparation of Glycerides Rich in Docosahexaenoic Acid from Thraustochytrid Single Cell Oils by Candida rugosa Lipase
• Identification and Expression of a Rat Fatty Acid Elongase Involved in the Biosynthesis of C18 Fatty Acids(Biochemistry & Molecular Biology)
• Lack of Effect of the Abnormal Fatty Acid Metabolism in NC/Nga Mice on Their Atopic Dermatitis
• Purification and Characterization of Sea Squirt α-N-Acetylgalactosaminidase
• Expression of a Major House Dust Mite Allergen Gene from Dermatophagoides farinae in Lotus japonicus Accession Miyakojima MG-20 (Plant Biotechnology)
• Production of Two Types of Phytase from Aspergillus oryzae during Industrial Koji Making
• Production and Properties of Phytase and Acid Phosphatase from a Sake Koji Mold,Aspergillus oryzae
• Production of Polyunsaturated Fatty Acids by Genetic Engineering of Yeast
• Effects of a Fermented Barley Extract on Subjects with Slightly High Serum Uric Acid or Mild Hyperuricemia
• Changes in Glucoamylases with Progress in a Culture of Aspergillus niger(Biological Chemistry)
• Effective Purification of Glucoamylase in Koji, a Solid Culture of Aspergillus oryzae on Steamed Rice, by Affinity Chromatography Using an Immobilized Acarbose (BAY g-5421)(Biological Chemistry)
• Comparative Studies of Various Molecular Species in Aspergillus niger Glucoamylase(Biological Chemistry)
• Various Molecular Species in Glucoamylase from Aspergillus niger(Biological Chemistry)
• Dietary Pulverized Konjac Glucomannan Prevents the Development of Allergic Rhinitis-Like Symptoms and IgE Response in Mice
• A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen
• Allixin Accumulation with Long-term Storage of Garlic
• Allixin Induction and Accumulation by Light Irradiation
• Sake Less Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation
• Improvement of Stearidonic Acid Production in Oleaginous Saccharomyces cerevisiae
• Anti-hyperuricemic Effect of Fermented Barley Extract is Associated with Increased Urinary Uric Acid Excretion
• Murine metabolism and absorption of lancemaside A, an active compound in the roots of Codonopsis lanceolata
• Adsorption of Glucoamylase in Unpasteurized Sake on an Affinity Column of Immobilized Glucoamylase Inhibitors
• Effects of Single and Combined Administration of Fermented Barley Extract and γ-Aminobutyric Acid on the Development of Atopic Dermatitis in NC/Nga Mice
• Effects of Fermented Barley Extract on Antioxidant Status in Mice
• Prophylactic effect of Lactobacillus oral vaccine expressing a Japanese cedar pollen allergen(MEDICAL BIOTECHNOLOGY)
• Prophylactic effect of Lactobacillus oral vaccine expressing a Japanese cedar pollen allergen
• Competitive advantage and tolerance of selected shochu yeast in barley shochu mash(BREWING AND FOOD TECHNOLOGY)
• Genetic instability of constitutive acid phosphatase in shochu and sake yeast(BREWING AND FOOD TECHNOLOGY)

もっと見る 閉じる

スポンサーリンク