SYNTHESIS OF VALPROYL-2-PYRROLIDINONE AND ITS EVALUATION AS A COGNITIVE DRUG WITH THE ABILITY TO MODULATE ACIDIC AMINO ACIDS IN THE BRAIN
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概要
- 論文の詳細を見る
A new pyrrolidinone derivative, valproyl-2-pyrrolidinone (VP), was synthesized, followed by evaluation as a cognitive drug. VP gave rise to a significant protective effect against cerebral anoxia together with a potent prolongation of latency time for the reversal of scopolamine induced transient disruption of the memory of a passive avoidance response in rats. The quantitative experiment using HPLC demonstrated a significant reduction of hippocampal aspartate (Asp) and glutamate (Glu) following the intraperitoneal administration of VP at a dose of 300 mg/kg.
- 公益社団法人日本薬学会の論文
著者
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ICHIKAWA Masataka
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
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Ichikawa M
Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.
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YAMAMOTO Junji
Department of Surgery, National Cancer Center Hospital
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GOTO Shigeru
Department of Industrial Chemistry, Faculty of Engineering, Kyoto University
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Matsuyama Kenji
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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Matsuyama Kenji
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Matsuyama Kenji
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
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Matsuyama Kenji
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Yamamoto Junji
Department Of Electrical Engineering Setsunan University
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MIYAZAKI Choichiro
Department of Hospital Pharmacy, Nagasaki University Hospital
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Matsuyama K
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Goto S
Faculty Of Pharmaceutical Sciences Kyushu University
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Miyazaki C
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
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Ichikawa Masataka
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Ichikawa Masataka
Department Of Pharmacy Nagasaki University Hospital
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Goto Shigeru
Department Of Hygiene Medical School Osaka University
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Miyazaki Choichiro
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
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Yamamoto Junji
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
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Goto Shigeru
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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ICHIKAWA MASATAKA
Department of Hospital Pharmacy, Nagasaki University School of Medicine
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ICHIKAWA MASATAKA
Department of Chemical Engineering, Kyushu University
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