HPLC Determination of (+)-Pseudoephedrine and (-)-Ephedrine in Japanese Herbal Medicines Containing Ephedra Herb Using Solid-Phase Extraction

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概要

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• We developed a rapid and simple HPLC method combined with solid-phase extraction (SPE) for quantitative analysis of (+)-pseudoephedrine (PEP) and (-)-ephedrine (EP) in Japanese herbal (Kampo) medicines such as Kakkon-to, Sho-seiryu-to, Goshaku-san and Bofu-tsusho-san. SPE was performed on TOYOPAK IC-SP M containing propylsulfonic groups. Determination of PEP and EP was carried out using ion-pair reversed-phase HPLC with sodium dodecyl sulfate. N-Benzyldiethylamine was used as an internal standard. The analytical procedure was validated with regard to specificity, linearity, accuracy, and precision. These data suggest that the analytical method developed in this study is useful for quantitative analysis of PEP and EP in various formulations of Kampo medicine containing Ephedra herb.

• 公益社団法人日本薬学会の論文
• 2003-06-01

著者

• MATSUURA Hiromichi

  Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd.,

• Imamura Kazuhiko

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Imamura Kazuhiko

  湧永製薬

• ICHIKAWA Makoto

  Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd.

• Ichikawa M

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Ichikawa Makoto

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Udayama M

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Udayama Manabu

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• SHIRAISHI Sumihiro

  Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd.

• Shiraishi S

  Wakunaga Pharmaceutical Co. Ltd. Hiroshima Jpn

• Shiraishi Sumihiro

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Matsuura H

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Matsuura Hiromichi

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

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