Topical Delivery System of Ophthalimic Drugs by Periocular Injection with Viscous Solution

スポンサーリンク

概要

• 論文の詳細を見る

• The purpose of this study is to evaluate periocular injections with viscous solution as a topical delivery system of ophthalmic drugs. Tilisolol and carboxymethylcellulose (CMC) were used as a model beta-blocker and a viscous polymer, respectively. After intracapsular, retrobulbar and palpebral conjuctival injections (50 μl) of tilisolol with 3% CMC into rabbits, drug concentrations in the tear fluid, blood, aqueous humor and vitreous body were determined by HPLC. Periocular injection (50 μl) of tilisolol with 3% CMC showed slight leakage of the drug in the tear fluid from the injection site. The viscous vehicle decreased the absorption rate constant of the drug from the injection site to systemic circulation compared with the buffer solution. It suggests that the viscous solution improved the retention of drug at both the injection site and in periocular tissues. Although the periocular injections with viscous vehicle (3% CMC) showed lower AUC in the aqueous humor than that observed in instillation, they showed comparable AUC in the vitreous humor. Compared to the results after the periocular injections with buffer solution, CMC increased the AUCs in the vitreous body 3.1-fold with retrobulbar injection and 1.4-fold with palpebral conjunctival injeciton, respectively. As a result, periocular injections with 3% CMC showed higher delivery of tilisolol to the vitreous body against the aqueous humor than the instillation and periocular injections with buffer solution.

• 公益社団法人日本薬学会の論文
• 1999-09-15

著者

• 中島 幹夫

  佐賀大学医学部附属病院 手術部

• Murakami T

  Kyoto Univ. Kyoto

• Kawakami Shigeru

  京都大学 薬学研究科

• Kawakami Shigeru

  Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• Sugahara Yazuyuki

  長崎大学 医歯薬学総合研究科臨床検査医学講座

• Sugahara Yazuyuki

  Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital

• NAKASHIMA Mikiro

  Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry

• SASAKI Hitoshi

  Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry

• Nakamura J

  Faculty Of Pharmaceutical Sciences Nagasaki University

• Nakamura Junzo

  長崎大学 薬

• Nakamura Junzo

  School Of Pharmaceutical Sciences Nagasaki University

• Nishida K

  Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.

• Nakashima M

  Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.

• Nakashima Mikiro

  Department Of Hospital Pharmacy Nagasaki University School Of Medicine

• Murakami T

  National Inst. Advanced Industrial Sci. And Technol. Ibaraki

• Hara Shintaro

  長崎大学 医学部第二内科

• Sasaki H

  Dep. Of Hospital Pharmacy Nagasaki Univ. Hospital

• Sakanaka Koji

  参天製薬奈良研究開発センター

• Tomonari Masahide

  参天製薬奈良研究開発センター

• Mukai T

  九州大学 大学院薬学研究院

• Mukai Takahiro

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Mukai Takahiro

  京都大学 薬学研究科病態機能分析学

• Mukai Takahiro

  Graduate School Of Medicine Kyoto University

• ICHIKAWA Masataka

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Nakano M

  Department Of Laboratory Medicine Nagasaki University School Of Medicine

• Ichikawa M

  Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.

• Mori Tomohiko

  Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University

• Sasaki Hitoshi

  長崎大学 医歯学部病院薬剤部

• Sasaki Hitoshi

  Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University

• NISHIDA Koyo

  School of Pharmaceutical Sciences, Nagasaki University

• MUKAI Takahiro

  School of Pharmaceutical Sciences, Nagasaki University

• KASHIWAGI Satsuki

  School of Pharmaceutical Sciences, Nagasaki University

• Kashiwagi Satsuki

  School Of Pharmaceutical Sciences Nagasaki University

• Sakanaka Koji

  Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry:santen Pharma

• Mukuno Takashi

  The Graduate School Of National Science And Technology Okayama University

• Ichikawa Masataka

  Department Of Hospital Pharmacy Nagasaki University School Of Medicine

• Ichikawa Masataka

  Department Of Pharmacy Nagasaki University Hospital

• Sasaki Hidetoshi

  Department Of Obstetrics And Gynecology Kinki University School Of Medicine

• ICHIKAWA MASATAKA

  Department of Hospital Pharmacy, Nagasaki University School of Medicine

• Nakashima Mikiro

  Department of Clinical Pharmacy, Graduate School of Biomedical Sciences, Nagasaki University

• ICHIKAWA MASATAKA

  Department of Chemical Engineering, Kyushu University

関連論文

• Antimicrobial susceptibility of respiratory tract pathogens in Japan during PROTEKT years 1-3 (1999-2002)
• No.19 ヒト血管平滑筋膜ラフトの精製と膜ラフトに局在する蛋白質のプロテオーム解析(一般演題,第110回山口大学医学会学術講演会並びに平成20年度山口大学医学会総会)
• O-9. Preparation of lipid raft from human vascular smooth muscle (VSM) and proteomic identification of its protein composition
• 0264 内皮由来過分極因子(EDHF)は内皮型NO合成酵素(eNOS)由来の非NO物質である可能性 : eNOSノックアウトマウスにおける検討
• P-404 米国の病院における医療事故防止対策と日本の病院の問題点
• 佐賀大学医学部における廃棄物処理の変遷
• 佐賀大学医学部附属病院における医療廃棄物処理の変遷
• 先天性無痛無汗症患者のプロポフォール単独による麻酔経験 : 術中の血中カテコラミン値の変化
• Analysis of Genetic Relationships and Antimicrobial Susceptibility of Verotoxin-Producing Escherichia coli Strains Isolated in Nagasaki Prefecture, Japan in 1996
• Serum Levels of Soluble Fas/APO-1 Receptor in Human Retroviral Infection and Associated Diseases
• 佐賀大学医学部附属病院における気管内手術時の麻酔管理の検討
• Comparison of the grade evaluated by "Liver damage" of Liver Cancer Study Group of Japan and Child-Pugh classification in patients with hepatocellular carcinoma
• Lung fibrosis 10 years after cessation of bleomycin therapy.
• PJ-585 Effects of Nasal Continuous Positive Airway Pressure on Left Ventricular Mass and Geometry in Obstructive Sleep Apnea Syndrome(PJ098,Obesity/SAS (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-212 Low-Density Lipoprotein Subfractions Separated by Anion-Exchange High Performance Chromatography Reflect Recent Oxidative Stress in Hypertensive Patients(PE036,Hypertension, Clinical 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting
• PJ-675 Abdominal Visceral Fat is Associated with not only Arteriosclerosis, but also Coronary Artery Spasm(Diabetes / Obesity / Metabolic syndrome(13)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Primary High-Grade Myofibroblastic Sarcoma Arising From the Pericardium
• PJ-330 Evaluation of Left Ventricular Function Using Tei-index in Obstructive Sleep Apnea Syndrome and Effect of Nasal Continuous Positive Airway Pressure(Cardiac function, basic/clinical-4 (M) PJ56,Poster Session (Japanese),The 70th Anniversary Annual Sc
• PE-422 IQGAP1 Regulates Reactive Oxygen Species-dependent Endothelial Cell Migration through Interacting with NAD (P) H Oxidase Subunit (Nox2)(Molecular biology, vascular-2 (H) PE71,Poster Session (English),The 70th Anniversary Annual Scientific Meeting o
• Chest Pain and ST Segment Depression Caused by Expansion of Gastric Tube Used for Esophageal Reconstruction
• A Probable Case of Aspiration Pneumonia Caused by Candida glabrata in a Non-neutropenic Patient with Candidemia
• Change in Pharmacokinetics of Model Compounds with Different Elimination Processes in Rats during Hypothermia
• Comparison of chest X-ray findings and other parameters in acute exacerbation of chronic bronchitis in Japan and the West
• Seroprevalence of Antibodies to Chlamydia spp.in Human Immunodeficiency Virus-Infected Subjects in Japan
• 佐賀医科大学医学部附属病院手術部における保険請求漏れに関する実態調査報告
• Highly stomach-selective gene transfer following gastric serosal surface instillation of naked plasmid DNA in rats.
• Cross-sectional Study on Relationship between Constipation and Medication
• Ocular Pharmacokinetic/Pharmacodynamic Modeling for Multiple Anti-glaucoma Drugs
• Influence of murine hepatitis induced by D-(+)-galactosamine hydrochloride and lipopolysaccharide on gene expression of polyethylenimine/plasmid DNA polyplex
• Absorption and Distribution Characteristics of 5-Fluorouracil (5-FU) after an Application to the Liver Surface in Rats in Order to Reduce Systemic Side Effects
• Ocular Pharmacokinetic/Pharmacodynamic Modeling for Timolol in Rabbits Using a Telemetry System
• Electrophysiological Characterization of Tight Junctional Pathway of Rabbit Cornea Treated with Ophthalmic Ingredients
• Spleen-Selective Gene Transfer Following the Administration of Naked Plasmid DNA onto the Spleen Surface in Mice
• Unilateral Lung-Selective Gene Transfer Following the Administration of Naked Plasmid DNA onto the Pulmonary Pleural Surface in Mice
• Transport of Timolol and Tilisolol in Rabbit Corneal Epithelium
• Stomach-Selective Gene Transfer Following the Administration of Naked Plasmid DNA onto the Gastric Serosal Surface in Mice
• Partial Hepatectomy Enhances Polyethylenimine-Mediated Plasmid DNA Delivery
• PEGylated Liposomes Loading Palmitoyl Prednisolone for Prolonged Blood Concentration of Prednisolone
• Effect of Solution Composition of Plasmid DNA on Gene Transfection Following Liver Surface Administration in Mice
• Stomach- and Site-Selective Delivery of 5-Fluorouracil Following Its Application on the Gastric Serosal Surface in Rats
• Unilateral Kidney-Selective Gene Transfer Following the Administration of Naked Plasmid DNA to the Kidney Surface in Mice
• Liver Site-Specific Gene Transfer Following the Administration of Naked Plasmid DNA to the Liver Surface in Mice
• Antimicrobial Activity of Saturated Fatty Acids and Fatty Amines against Methicillin-Resistant Staphylococcus aureus
• Pharmacokinetics of Phenol Red in Rat Models of Liver Damage Prepared by Liver Targeting of Carbon Tetrachloride
• Transport of Acebutolol through Rabbit Corneal Epithelium
• Radiosynthesis and Biodistribution in Mice of a ^F-Labeled Analog of O-1302 for Use in Cerebral CB1 Cannabinoid Receptor Imaging(Medicinal Chemistry)
• Synthesis of a β-Tetrapeptide Analog as a Mother Compound for the Development of Matrix Metalloproteinase-2-Imaging Agents
• Ascorbate Analogs for Use in Medical Imaging : Synthesis and Radical Scavenging Activity of 5-O-(4'-Iodobenzyl)-L-ascorbic Acid
• Methoxy- and Fluorine-Substituted Analogs of O-1302 : Synthesis and in Vitro Binding Affinity for the CB1 Cannabinoid Receptor
• Radiosynthesis and Evaluation of ^C-Labeled Diaryl-Substituted Imidazole and Indole Derivatives for Mapping Cyclooxygenase-2(Biopharmacy)
• Decreased Tissue Accumulation of 6-Deoxy-6-[^F]fluoro-L-ascorbic Acid in Glutathione-Deficient Rats Induced by Administration of Diethyl Maleate(Biopharmacy)
• Intracellular Trafficking Is the Important Process That Determines the Optimal Charge Ratio on Transfection by Galactosylated Lipoplex in HepG2 Cells(Biopharmacy)
• Effect of the Particle Size of Galactosylated Lipoplex on Hepatocyte-Selective Gene Transfection after Intraportal Administration(Biopharmacy)
• Effect of Low-Molecular-Weight β-Cyclodextrin Polymer on Release of Drugs from Mucoadhesive Buccal Film Dosage Forms(Biopharmacy)
• Lipid Carrier Systems for Targeted Drug and Gene Delivery
• Analysis of Hepatic Disposition of Native and Galactosylated Polyethylenimine Complexed with Plasmid DNA in Perfused Rat Liver
• Development of Chemical Probes for the Chemokine Receptor CXCR4 Involving Radiolabeled T140 Analogs
• Adult Still's disease associated with cytomegalovirus infection
• Acetazolamide assisted Tc-99m MAG3 renography to assess renal blood flow reserve
• Active repression of IFN regulatory factor-1-mediated transactivation by IFN regulatory factor-4
• Long-Term Macrolide Antibiotic Therapy in the Treatment of Chronic Small Airway Disease Clinically Mimicking Diffuse Panbronchiolitis
• Adhesion-dependent growth of primary adult T cell leukemia cells with down-regulation of HTLV-I p40Tax protein : a novel in vitro model of the growth of acute ATL cells
• 開発途上国における挿管困難症例に対し, トラキライト^が有用であった1例
• A Novel Plasmacytoid Dendritic Cell Line, CAL-1, Established from a Patient with Blastic Natural Killer Cell Lymphoma
• Clinical and Oncologic Implications in Epigenetic Down-Regulation of CD26/Dipeptidyl Peptidase IV in Adult T-Cell Leukemia Cells
• Clinical Relevance of Survivin as a Biomarker in Neoplasms, Especially in Adult T-Cell Leukemias and Acute Leukemias
• Real-Time Polymerase Chain Reaction for Quantification of HTLV-1 Proviral Load: Application for Analyzing Aberrant Integration of the Proviral DNA in Adult T-Cell Leukemia
• Development of Peptide Tools for Fluorescence Imaging of Proteins in Living Cells
• Renoprotective Effect of Azelnidipine in Rats
• PII-05 Local Production of Leptin may Affect the Progression of Peritoneal Fibrosis in a Mouse Model with Chlorhexidine Gluconate
• PI-09 Synthetic Retinoid Am80, an Inhibitor of Kruppel-like Factor5 (Klf5) Ameliorates the Progression of Mouse Peritoneal Fibrosis
• Invasive Pulmonary Aspergillosis Diagnosed Early by Polymerase Chain Reaction Assay
• Respiratory Bronchiolitis-associated Interstitial Lung Disease with Unusual Histopathological Findings
• 手術時手洗い実習の細菌培養による評価の試み
• Further Studies on the Kidney- and Site-Selective Delivery of 5-Fluorouracil Following Kidney Surface Application in Rats
• Effect of the Absorption Enhancer Saponin on the Intrarenal Distribution of 5-Fluorouracil Following Its Kidney Surface Application in Rats
• Kidney- and Site-Selective Delivery of 5-Fluorouracil Utilizing the Absorption on the Kidney Surface in Rats
• バイオクリーン手術室における清浄度
• 小児における気管切開の気管肉芽形成に関する検討
• P-345 硫酸ポリミキシン B の酵素免疫測定法による血中濃度測定とその抗エンドトキシン作用について
• Effect of Carboxylation of N-Terminal Phenylalamne of ^In-DTPA (Diethylenetriaminepentaacetic Acid)-Octreotide on Accumulation of Radioactivity in Kidney(Communications to the Editor)
• A Novel Method for Preparation of Animal Models of Liver Damage: Liver Targeting of Carbon Tetrachloride in Rats
• Biodistribution and Pharmacokinetics of O-Palmitoyl Tilisolol, a Lipophilic Prodrug of Tilisolol, after Intravenous Administration in Rats
• Continuous Microinstillation of Phenol Red on Liver Surface for Liver Site-Selective Delivery
• Modification of Ocular Permeability of Peptide Drugs by Absorption Promoters
• Pharmacokinetic Prediction of the Ocular Absorption of an Instilled Drug with Ophthalmic Viscous Vehicle
• Characterization of Ocular Pharmacokinetics of Tilisolol after Instillation into Anesthetized Rabbits
• Topical Delivery System of Ophthalimic Drugs by Periocular Injection with Viscous Solution
• Drug Absorption Behavior after Periocular Injections
• Induction of Micronuclei in CHO Cells by Bleomycin but not by X-irradiation is Decreased by Treatment with HMG-CoA Reductase Inhibitors
• A Highly Sensitive ELISA for the Quantification of Polymyxin B Sulfate in Human Serum
• ヒト冠動脈と血管内皮由来過分極因子(EDHF)
• Evaluation of Newly Developed Oxygen Meters with Multi-Channels and Disposable Oxygen Electrode Sensors for Antimicrobial Susceptibility Testing
• Influence of liver disease on phenolsulfonphthalein absorption from liver surface to examine possibility of direct liver surface application for drug targeting,
• Local Distribution into Brain Tumor and Pharmacokinetics of 4-Pyridoxate Diammine Hydroxy Platinum, a Novel Cisplatin Derivative, after Intracarotid Administration in Rats with 9L Malignant Glioma : Simultaneous Brain Microdialysis Study
• In Vitro Characteristics and in Vivo Plasma Disposition of Cisplatin Conjugated with Oxidized and Dicarboxymethylated Dextrans
• Antitumour Effects of 4-Pyridoxate Diammine Hydroxy Platinum, a Novel Cisplatin Derivative, Against Gliomas In-vitro and In-vivo : A Comparison with Cisplatin.
• In Vivo Microdialysis to Determine the Relative Pharmacokinetics of Drugs
• Structure-Activity Relationship Study of CXCR4 Antagonists on the Cyclic Pentapeptide Scaffold : Identification of New Pharmacophore Moieties
• Development of a Novel Tag-Probe System for Fluorescent Imaging of Proteins in Living Cells

もっと見る 閉じる

スポンサーリンク