Decreased Tissue Accumulation of 6-Deoxy-6-[^<18>F]fluoro-L-ascorbic Acid in Glutathione-Deficient Rats Induced by Administration of Diethyl Maleate(Biopharmacy)
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概要
- 論文の詳細を見る
The relationship between in vivo biodistribution of 6-deoxy-6-[^<18>F]fluoro-L-ascorbic acid (^<18>F-DFA) and the content of tissue glutathione (GSH) was investigated in Wistar male rats. Following intravenous administration of ^<18>F-DFA, the accumulation of radioactivity in most tissues, including the adrenal glands, liver and brain, was significantly reduced together with a decrease in the content of GSH by preloading of diethyl maleate (DEM) which depletes cellular GSH. Similar decreased uptake was also observed in the distribution of L-[1-^<14>C]ascorbic acid (^<14>C-AA) after DEM treatment. The possible biological mechanisms, including competition with endogenous AA and ascorbate recycling, that modulate the uptake and accumulation into tissues of ^<18>F-DFA and ^<14>C-AA in GSH-deficient rats are discussed.
- 社団法人日本薬学会の論文
- 2005-10-01
著者
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Murakami T
Kyoto Univ. Kyoto
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Murakami T
National Inst. Advanced Industrial Sci. And Technol. Ibaraki
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Tomonari Masahide
参天製薬奈良研究開発センター
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Mukai T
九州大学 大学院薬学研究院
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Mukai Takahiro
Graduate School Of Pharmaceutical Sciences Kyushu University
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Mukai Takahiro
京都大学 薬学研究科病態機能分析学
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Mukai Takahiro
Graduate School Of Medicine Kyoto University
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MAEDA Minoru
Graduate School of Pharmaceutical Sciences, Kyushu University
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KATO Hiroharu
Graduate School of Pharmaceutical Sciences, Kyushu University
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YAMAMOTO Fumihiko
Faculty of Pharmaceutical Sciences, Kyushu University
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KANESHIRO Tetsuo
Faculty of Pharmaceutical Sciences, Kyushu University
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KATO Hiroharu
Faculty of Pharmaceutical Sciences, Kyushu University
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MUKAI Takahiro
Faculty of Pharmaceutical Sciences, Kyushu University
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KUWABARA Yasuo
Faculty of Medical Sciences, Kyushu University
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HONDA Hiroshi
Faculty of Medical Sciences, Kyushu University
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MAEDA Minoru
Faculty of Pharmaceutical Sciences, Kyushu University
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Mori Tomohiko
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Kato Hiroharu
Graduate School Of Pharmaceutical Sciences Kyushu University
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Kuwabara Yasuo
Department Of Radiology Faculty Of Medicine Fukuoka University
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Kuwabara Yasuo
Dep. Of Radiology School Of Medicine Fukuoka Univ.
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Honda Hiroshi
Dep. Of Clinical Radiology Graduate School Of Medical Sciences Kyushu Univ.
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Kuwabara Yasuo
Graduate School Of Medical Sciences Kyushu University
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Kaneshiro Tetsuo
Graduate School Of Pharmaceutical Sciences Kyushu University
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Maeda Minoru
Optical Measurement Technology Development Co. Ltd.
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Maeda Minoru
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamamoto Fumihiko
Graduate School Of Pharmaceutical Sciences Kyushu University:crest Japan Sceicne And Technology Corp
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Yamamoto Fumihiko
Graduate School Of Pharmaceutical Sciences Kyushu University
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Maeda M
Graduate School Of Pharmaceutical Sciences Kyushu University
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Kato Hiroharu
Faculty Of Engineering The University Of Tokyo
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Kuwabara Y
Department Of Radiology Faculty Of Medicine Fukuoka University
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Mukuno Takashi
The Graduate School Of National Science And Technology Okayama University
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Yasumori Kotaro
Neuroradiology Cerebrovascular Center And Clinical Research Institute National Kyushu Medical Center
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Kuwabara Yasuo
Kyushu Univ. Hospital Fukuoka Jpn
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Honda Hiroshi
Faculty Of Medical Sciences Kyushu University
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Maeda Minoru
Faculty Of Pharmaceutical Sciences Kyushu University
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